ARAF and PIK3CA

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ARAF	PIK3CA
Description		A-Raf proto-oncogene, serine/threonine kinase	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Intercalated Disc Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Protein Kinase Activator Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Signal Transduction Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Protein Modification Process Negative Regulation Of Apoptotic Process	Angiogenesis Liver Development Vasculature Development Glucose Metabolic Process Lipid Metabolic Process Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Response To Activity Response To Muscle Inactivity Negative Regulation Of Macroautophagy Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Response To Muscle Stretch Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Multicellular Organism Growth Response To L-leucine Anoikis Regulation Of Cellular Respiration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Phosphatidylinositol Phosphate Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Adipose Tissue Development Cellular Response To Glucose Stimulus Cellular Response To Hydrostatic Pressure Response To Dexamethasone Cardiac Muscle Cell Contraction Energy Homeostasis Regulation Of Actin Filament Organization Autosome Genomic Imprinting Response To Butyrate Positive Regulation Of Protein Localization To Membrane Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Anoikis
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		ATP	ATP Caffeine XL765 Wortmannin Pilaralisib Alpelisib Copanlisib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Ovarian cancer
GWAS			Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		57 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	69 interacting genes: ADAP1 AKT1 AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FANCC FASLG FBP2 FTL GABRB1 GALNT12 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK MAP2K1 MRAS MYC NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PSMC3IP PTPN11 RASD2 RASGRP3 RELA RPS20 RPS6KB1 SFRP4 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TMOD1 TNFSF13 UFD1 UMPS VARS2
Entrez ID		369	5290
HPRD ID		02405	01382
Ensembl ID		ENSG00000078061	ENSG00000121879
Uniprot IDs		A0A024R178 P10398 Q96II5	P42336
PDB IDs		1WXM 2MSE 9AXM	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS 6VO7 7JIU 7K6M 7K6N 7K6O 7K71 7L1B 7L1C 7L1D 7MLK 7MYN 7MYO 7PG5 7PG6 7R9V 7R9Y 7RRG 7TZ7 8AM0 8BFU 8DCP 8DCX 8DD4 8DD8 8EXL 8EXO 8EXU 8EXV 8GUA 8GUB 8GUD 8ILR 8ILS 8ILV 8OW2 8SBC 8SBJ 8TDU 8TGD 8TS7 8TS8 8TS9 8TSA 8TSB 8TSC 8TSD 8TU6 8TWY 8V8H 8V8I 8V8J 8V8U 8V8V 8VCL 8W9A 8W9B 9ASF 9ASG 9B4S 9B4T 9C15 9E8M
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Nucleotide Binding Intracellular Signaling Cassette ATP Binding Regulation Of Intracellular Signal Transduction Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Organization MAP Kinase Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction MAPK Cascade Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Regulation Of Protein Localization Regulation Of Catalytic Activity Regulation Of Cell Cycle Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization To Membrane Apoptotic Signaling Pathway Cellular Response To Radiation Regulation Of Cellular Localization Negative Regulation Of Macroautophagy Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Primary Metabolic Process	Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Apoptotic Process Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Cytosol Kinase Activity Positive Regulation Of D-glucose Import Cytoplasm Cell Population Proliferation Regulation Of Protein Localization To Cell Periphery Response To UV Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of D-glucose Transmembrane Transport Cell Migration Nucleotide Binding Negative Regulation Of Programmed Cell Death Response To Radiation Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Phospholipase C Activator Activity MAPK Cascade Response To Hormone Protein Kinase Binding Regulation Of Protein Modification Process Cell Motility Response To Growth Factor Response To Light Stimulus Negative Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of D-glucose Import Positive Regulation Of Gene Expression Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Positive Regulation Of Metabolic Process
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