ITGA5 and THAP1

		ITGA5	THAP1
Description		integrin subunit alpha 5	THAP domain containing 1
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GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Resveratrol Tauroursodeoxycholic acid
Diseases			Primary torsion dystonia (PTD)
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		3678	55145
HPRD ID		00627	15496
Ensembl ID		ENSG00000161638	ENSG00000131931
Uniprot IDs		B2R627 P08648	Q9NVV9
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV	2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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