THAP1 and KLF12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		THAP1	KLF12
Gene Name		THAP domain containing, apoptosis associated protein 1	Kruppel-like factor 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Pancreatic cancer ( 20101243) Phospholipid levels (plasma) ( 22359512) Ventricular conduction ( 21076409)
Protein-Protein Interactions		58 interactors: ACOT7 AKAP17A AKAP9 AP2B1 ARL6IP4 BAG5 BMS1P5 BYSL C11orf57 C1orf35 C7orf50 CHD2 CSNK2A1 DCAF8 DVL2 FAM124A FAM133A FXR2 GPATCH2L HNRNPLL KLF12 KRTAP10-7 LASP1 MORF4L1 MORF4L2 MRPL11 NKAP NUP62 PAWR PHF1 PID1 POLR2L POLR2M PPIG PRKAA1 PRR20A QKI RALYL RBM39 RIPPLY1 RP9P RPS25 SAP30BP SERF2 SLU7 STRBP TCEA2 TPM3 TRAF5 TRIM26 TTLL10 TXN2 U2AF2 WDYHV1 YES1 ZCCHC10 ZNF385C ZNF408	4 interactors: APP CTBP1 EHMT2 THAP1
Entrez ID		55145	11278
HPRD ID		15496	06336
Ensembl ID		ENSG00000131931	ENSG00000118922
Uniprot IDs		Q9NVV9	Q8WWI3 Q9Y4X4
PDB IDs		2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Metabolic Process Regulation Of Gene Expression RNA Splicing Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Processing MRNA Processing Cellular Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Metabolic Process Positive Regulation Of Gene Expression Metabolic Process Negative Regulation Of Glucose Import Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Gene Expression, Epigenetic Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Negative Regulation Of Gene Expression Segment Specification Positive Regulation Of Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Glucose Transport Regulation Of RNA Splicing Regulation Of Protein Metabolic Process MRNA Transport Fatty Acid Biosynthetic Process Positive Regulation Of RNA Splicing Palmitic Acid Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Maintenance Of ER Location Negative Regulation Of Glucosylceramide Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Cell Cycle Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury DNA Methylation On Cytosine Within A CG Sequence Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Neuron Remodeling Negative Regulation Of Histone H4 Acetylation Histone H3-K27 Methylation Histone Modification Regulation Of Cellular Amino Acid Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Peptidyl-lysine Dimethylation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Growth Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Histone H4 Acetylation White Fat Cell Differentiation Endothelial Cell Proliferation Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Deacetylation Histone H3-K9 Methylation Chromatin Modification Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Peptidyl-lysine Acetylation Synaptonemal Complex Assembly Negative Regulation Of Protein Acetylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Organization Viral Genome Replication Positive Regulation Of Protein Deacetylation Neuron Maturation
Tagcloud ?		assembled childhood compatible confirms contiguous definite deletions distinctive dystonia dyt1 eighty gch1 imprinted ireland laxity maternally microcephaly myoclonus nineteen nkx2 phenotypically probable probands progressing sequenced sgce stature uk upper	aberrations arrays caucasian cdkn2a cna cnas copy curative decades deleted discovered driver eac esophageal esophagectomy fhit frequent gistic heterozygosity intent oncogenes ptprd regions residing smad4 snp stratified suitable targetable
Tagcloud (Difference) ?		assembled childhood compatible confirms contiguous definite deletions distinctive dystonia dyt1 eighty gch1 imprinted ireland laxity maternally microcephaly myoclonus nineteen nkx2 phenotypically probable probands progressing sequenced sgce stature uk upper	aberrations arrays caucasian cdkn2a cna cnas copy curative decades deleted discovered driver eac esophageal esophagectomy fhit frequent gistic heterozygosity intent oncogenes ptprd regions residing smad4 snp stratified suitable targetable
Tagcloud (Intersection) ?