THAP1 and LMO3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THAP1	LMO3
Description		THAP domain containing 1	LIM domain only 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Chronotype ( 30696823) Household income (MTAG) ( 31844048) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Smoking initiation ( 33082346) Tourette syndrome ( 30818990) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526	124 interacting genes: ABI2 ACTMAP AIMP2 AMIGO1 AMOTL2 AVPI1 BANP BCAS2 BEND5 BEND7 BHLHE40 BLZF1 CARD9 CARF CBY2 CCDC33 CCDC85B CCSER1 CDYL2 CEP170P1 CEP57 CEP57L1 CYSRT1 DCDC2 DVL2 DYRK1A FAM131C FBLIM1 FOS GABPB1 GMEB2 GOLGA2 GOLGA6L9 GPATCH2L HMBOX1 HNRNPC HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IL16 INCA1 ITSN1 KANK2 KCTD1 KIF2A KRABD4 KRT31 KRT38 KXD1 LDB1 LDB2 LIMS1 LNPK LPXN LZTS1 LZTS2 MAD1L1 MALSU1 MBD3 MBD3L1 MBIP MDFI MEIS3 MID2 MTUS2 MYOG MYOZ3 NBPF22P NDOR1 NFKBID NHLH2 NIF3L1 NTAQ1 NUTM1 PELO PHC2 PICK1 PNMA1 POU6F2 PPP1R13B PXN QRICH1 RALYL RCN1 RFC5 RFX6 RORA SAMD3 SH2B2 SHISA6 SLAIN1 SP4 TAX1BP1 TCP10L TEPSIN THAP1 TMEM121 TRAPPC2L TRIB3 TRIM23 TRIM54 TUFT1 USP54 VBP1 VMAC VPS28 WASHC1 WWOX ZBTB43 ZBTB8A ZBTB8B ZIM3 ZNF143 ZNF526 ZNF587 ZNF620 ZNF641 ZNF69 ZNF84 ZRANB1 ZSCAN9
Entrez ID		55145	55885
HPRD ID		15496	11832
Ensembl ID		ENSG00000131931	ENSG00000048540
Uniprot IDs		Q9NVV9	Q8TAP4 Q9NYC6
PDB IDs		2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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