THAP1 and FGF12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THAP1	FGF12
Description		THAP domain containing 1	fibroblast growth factor 12
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Extracellular Space Nucleus Cytoplasm Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	Signal Transduction JNK Cascade Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neurogenesis Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity
Pathways			Phase 0 - rapid depolarisation
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder ( 31043756) Fasting glucose ( 34059833) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels in HIV infection ( 33109212) Height ( 32902719) Hip circumference adjusted for BMI ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe influenza A (H1N1) infection ( 26379185) Sleep quality ( 23728906)
Interacting Genes		105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526	25 interacting genes: APP COIL CT45A1 DACH1 DCTD DPPA2 GRIP1 IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 RBAK RNF151 RP9 SMURF1 SRPK1 SRPK2 STAC3 THAP1 YWHAE ZNF460 ZNF79
Entrez ID		55145	2257
HPRD ID		15496	03303
Ensembl ID		ENSG00000131931	ENSG00000114279
Uniprot IDs		Q9NVV9	A0A804HIN2 C9JEN8 P61328
PDB IDs		2JTG 2KO0 2L1G	1Q1U 4JQ0
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation	Receptor Catabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Sodium Channel Inhibitor Activity Phosphoserine Residue Binding Receptor Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Internalization Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Zinc Ion Binding Positive Regulation Of Dendrite Extension Regulation Of Membrane Potential Mating Behavior Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Transmembrane Transport Positive Regulation Of Receptor Internalization Protein Polyubiquitination Negative Regulation Of Potassium Ion Transport Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Binding Positive Regulation Of Transport Reproductive Behavior Negative Regulation Of Fibroblast Proliferation Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Regulation Of Membrane Repolarization Engulfment Of Target By Autophagosome Primary Ureteric Bud Growth Regulation Of Toll-like Receptor Signaling Pathway
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