THAP1 and RPL22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THAP1	RPL22
Description		THAP domain containing 1	ribosomal protein L22
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	Cytoplasmic Translation Translation Alpha-beta T Cell Differentiation Translation At Presynapse
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) TPE interval (resting) ( 32386560)
Interacting Genes		105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526	27 interacting genes: AP2M1 BAG4 BEND7 CALM1 CDC42 CSE1L CT45A1 DDIT4L DUX4 FGF11 FOXP1 H2BC15 IL7R MAPK14 MDM2 NSFL1C OGT PTEN SDCBP SDCBP2 SLC26A4-AS1 SNCA SRPK2 STAC3 SURF6 THAP1 ZCCHC10
Entrez ID		55145	6146
HPRD ID		15496	01602
Ensembl ID		ENSG00000131931	ENSG00000116251
Uniprot IDs		Q9NVV9	P35268
PDB IDs		2JTG 2KO0 2L1G	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation	Lipid Binding Regulation Of Cell Cycle Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Presynaptic Endocytosis Positive Regulation Of Cell Population Proliferation Regulation Of Protein Localization Nucleoplasm Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Cycle Process Regulation Of Endocytosis Regulation Of Cell Population Proliferation Cellular Component Assembly Response To Cytokine Response To Peptide Regulation Of Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Transport Cytosol Response To Magnesium Ion Dendritic Spine Morphogenesis Vesicle-mediated Transport In Synapse Regulation Of Organ Growth Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Response To Type II Interferon Regulation Of Transport Regulation Of Cellular Component Size Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Communication Nucleus Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Adhesion Dendritic Spine Organization Regulation Of Synapse Organization Negative Regulation Of Protein-containing Complex Assembly Identical Protein Binding Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Localization Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process
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