THAP1 and NDUFAB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THAP1	NDUFAB1
Description		THAP domain containing 1	NADH:ubiquinone oxidoreductase subunit AB1
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Membrane Respiratory Chain Complex I Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Acyl Binding Acyl Carrier Activity Structural Molecule Activity Fatty Acid Binding Calcium Ion Binding Protein Binding Mitochondrial Large Ribosomal Subunit Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle	Mitochondrial Electron Transport, NADH To Ubiquinone Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Aerobic Respiration Protein Lipoylation Iron-sulfur Cluster Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis [2Fe-2S] Cluster Assembly
Pathways			Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation Protein lipoylation Mitochondrial ribosome-associated quality control
Drugs			NADH
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Bipolar disorder ( 17554300)
Interacting Genes		105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526	35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829
Entrez ID		55145	4706
HPRD ID		15496	11951
Ensembl ID		ENSG00000131931	ENSG00000004779
Uniprot IDs		Q9NVV9	O14561
PDB IDs		2JTG 2KO0 2L1G	2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD 7A5H 7A5J 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF5 7OF7 7OI6 7OI7 7OI8 7OI9 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 8K2B 8PK0 8QSJ 8QU5
Enriched GO Terms of Interacting Partners?		Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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