RABIF and ITGA5

Number of citations of the paper that reports this interaction (PMID 10094488)
9

Data Source:
BioGRID (two hybrid)

		RABIF	ITGA5
Gene Name		RAB interacting factor	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
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Gene Ontology Annotations	Cellular Component		Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of GTPase Activity Membrane Fusion	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis
Pathways			Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CCBL2 ITGA2 ITGA3 ITGA5 ITGA6 LAMTOR5 RAB15 RAB1A RAB3A RAB8A RASSF5 REL TCF4 TERF2IP UTP14A	24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC
Entrez ID		5877	3678
HPRD ID		04566	00627
Ensembl ID			ENSG00000161638
Uniprot IDs		P47224 Q53EV1	P08648
PDB IDs		1FWQ 2FU5	3VI3 3VI4
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Cell Adhesion Mediated By Integrin Cell-substrate Adhesion Integrin-mediated Signaling Pathway Protein Secretion Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Metabolic Process Protein Localization Vesicle Docking Involved In Exocytosis Vesicle Localization Cellular Protein Localization Ras Protein Signal Transduction Skin Development Vesicle Docking Regulation Of Cellular Localization Membrane Docking Signal Transduction Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Glycoprotein Metabolic Process Response To Stimulus Positive Regulation Of Cell-substrate Adhesion Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Signaling Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Formation Of Primary Germ Layer Positive Regulation Of Regulated Secretory Pathway Cell Communication Organelle Localization Cellular Component Maintenance Regulation Of Exocytosis Blood Coagulation Cell Migration Hemostasis Cell-matrix Adhesion Response To Extracellular Stimulus Mesodermal Cell Differentiation Establishment Of Protein Localization Cell Motility Intracellular Protein Transport Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Viral Life Cycle Gastrulation Generation Of Neurons	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction
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