INCENP and HIST2H3C

Number of citations of the paper that reports this interaction (PMID 20929775)
64

Data Source:
BioGRID (pull down)

		INCENP	HIST2H3C
Gene Name		inner centromere protein antigens 135/155kDa	histone cluster 2, H3c
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Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C	61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1
Entrez ID		3619	126961
HPRD ID		05103	11822
Ensembl ID		ENSG00000149503
Uniprot IDs		Q9NQS7	Q71DI3
PDB IDs		2QFA 4AF3	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?