INCENP and H2AFZ

Number of citations of the paper that reports this interaction (PMID 12660166)
47

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		INCENP	H2AFZ
Gene Name		inner centromere protein antigens 135/155kDa	H2A histone family, member Z
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex	Nucleosome Barr Body Nucleus Nuclear Euchromatin Nuclear Heterochromatin Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division	Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C	3 interactors: INCENP MAGEC1 NCAPH
Entrez ID		3619	3015
HPRD ID		05103	00823
Ensembl ID		ENSG00000149503	ENSG00000164032
Uniprot IDs		Q9NQS7	P0C0S5
PDB IDs		2QFA 4AF3	1F66
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding	Chromosome Segregation Mitotic Nuclear Division Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Mitotic Chromosome Condensation Cell Cycle Chromosome Condensation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cytokinesis DNA Packaging Organelle Organization DNA Conformation Change
Tagcloud ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	adrbk1 bisulfite ccne2 chimpanzee crabp1 cxcl6 derive dsc2 ega embryos endangered gapdh glut1 h3k27 h4k5 interspecies iscnt klf4 lin28 nanog oct4 ooplasm ptger4 remodel scnt soon stella usf2 utp
Tagcloud (Difference) ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	adrbk1 bisulfite ccne2 chimpanzee crabp1 cxcl6 derive dsc2 ega embryos endangered gapdh glut1 h3k27 h4k5 interspecies iscnt klf4 lin28 nanog oct4 ooplasm ptger4 remodel scnt soon stella usf2 utp
Tagcloud (Intersection) ?