INCENP and CDCA8

Number of citations of the paper that reports this interaction (PMID 15249581)
105

Data Source:
HPRD (in vivo, in vitro)

		INCENP	CDCA8
Gene Name		inner centromere protein antigens 135/155kDa	cell division cycle associated 8
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex	Chromosome, Centromeric Region Nucleus Nucleolus Spindle Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein Complex Intercellular Bridge
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division	Mitotic Cell Cycle Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C	14 interactors: AURKB BIRC5 HIST2H3C HLA-DRB3 INCENP MAPKAPK5 NEK3 RANBP2 SGOL1 SGOL2 SUMO1 SUMO2 TTK UBE2I
Entrez ID		3619	55143
HPRD ID		05103	13017
Ensembl ID		ENSG00000149503	ENSG00000134690
Uniprot IDs		Q9NQS7	Q53HL2
PDB IDs		2QFA 4AF3	2KDD 2QFA 2RAW 2RAX
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding	Chromosome Segregation Mitotic Cell Cycle Cell Cycle Process Protein Sumoylation Mitotic Cell Cycle Process Cell Division Cell Cycle Mitotic Nuclear Division Organelle Organization Spindle Checkpoint Mitotic Spindle Organization Peptidyl-amino Acid Modification Peptidyl-lysine Modification Cellular Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Protein Modification By Small Protein Conjugation Cytokinesis Spindle Organization Mitotic Spindle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Microtubule Cytoskeleton Organization Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Division Regulation Of Proteolysis Microtubule Anchoring Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of SUMO Transferase Activity Protein Phosphorylation Negative Regulation Of Gene Expression Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule-based Process Meiotic Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Protein Metabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Protein Catabolic Process Negative Regulation Of Binding Histone H3-S28 Phosphorylation
Tagcloud ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability