IGF2 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		IGF2	TRIM63
Description		insulin like growth factor 2	tripartite motif containing 63
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926 32499647) Urate levels ( 31578528)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN	331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		3481	84676
HPRD ID		00939	05843
Ensembl ID		ENSG00000167244	ENSG00000158022
Uniprot IDs		E3UN46 P01344	Q969Q1
PDB IDs		1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility	Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding
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