IGF2 and IDE

Number of citations of the paper that reports this interaction (PubMedID 1733942)
0

Data Source:
HPRD (in vitro)

		IGF2	IDE
Description		insulin like growth factor 2	insulin degrading enzyme
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Nucleotide Binding Amyloid-beta Binding Virus Receptor Activity Catalytic Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Peptide Hormone Binding Beta-endorphin Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation	Proteolysis Insulin Receptor Signaling Pathway Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Ub-specific processing proteases Insulin receptor recycling Peroxisomal protein import Peroxisomal protein import
Drugs			Bacitracin
Diseases		Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926 32499647) Urate levels ( 31578528)	Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 27680694 31043758) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 20581827 22885922 24509480 26818947 29358691 30297969 30718926 32499647) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN	9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5
Entrez ID		3481	3416
HPRD ID		00939	00894
Ensembl ID		ENSG00000167244	ENSG00000119912
Uniprot IDs		E3UN46 P01344	A0A3B3ISG5 A0A7I2V2P6 A0A7I2V373 B3KSB8 P14735
PDB IDs		1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC	2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3 7K1D 7K1E 7K1F 7RZE 7RZF 7RZG 7RZH 7RZI
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Regulation Of Glucose Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Growth Regulation Of Developmental Growth Receptor Ligand Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Glycolytic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Cellular Response To Oxygen-containing Compound Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Exocrine Pancreas Development Positive Regulation Of Growth Insulin Receptor Signaling Pathway Regulation Of Purine Nucleotide Metabolic Process Estrogen Response Element Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process
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