IGF2 and IGFBP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		IGF2	IGFBP1
Description		insulin like growth factor 2	insulin like growth factor binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Response To Insulin Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases		Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926 32499647) Urate levels ( 31578528)	Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)
Interacting Genes		26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN	4 interacting genes: IGF1 IGF2 MMP26 TF
Entrez ID		3481	3484
HPRD ID		00939	00897
Ensembl ID		ENSG00000167244	ENSG00000146678
Uniprot IDs		E3UN46 P01344	P08833
PDB IDs		1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC	1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility	Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Space Platelet Alpha Granule Lumen Striated Muscle Cell Differentiation Insulin Receptor Signaling Pathway Regulation Of Organ Growth Regulation Of Glucose Metabolic Process Positive Regulation Of T Cell Proliferation Muscle Cell Differentiation Negative Regulation Of Oocyte Development Extracellular Region Hormone Activity Regulation Of Mitotic Nuclear Division Receptor Ligand Activity Osteoblast Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Integrin Binding Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Trophectodermal Cell Proliferation Growth Factor Activity Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Nuclear Division Regulation Of Muscle Cell Differentiation Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Growth Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Glycolate Metabolic Process Negative Regulation Of Inflammatory Response Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alphav-beta3 Integrin-IGF-1-IGF1R Complex Prostate Gland Stromal Morphogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Type B Pancreatic Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?