RSPO2 and PLEKHF2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RSPO2	PLEKHF2
Gene Name		R-spondin 2	pleckstrin homology domain containing, family F (with FYVE domain) member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Heparin Binding	Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Transport
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)	Radiation response ( 20923822)
Protein-Protein Interactions		8 interactors: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 PLEKHF2 SUV39H1	52 interactors: ACY3 AIMP2 APP APPL1 BEND7 BLOC1S6 BSCL2 CCDC85B CEP44 CHIC2 DTX2 DUT FBXO28 FHL3 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NONO NPM2 PRKAR1A PRPSAP1 RABAC1 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SDPR SEPT2 SEPT6 SETBP1 SFN SPEF1 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z ZNF250 ZNF263 ZNF398
Entrez ID		340419	79666
HPRD ID		17536	15147
Ensembl ID		ENSG00000147655	ENSG00000175895
Uniprot IDs		B3KVP3 Q6UXX9	Q9H8W4
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Peptidyl-lysine Modification Rhythmic Process Kidney Development Histone H3-K9 Dimethylation Renal System Development Recognition Of Apoptotic Cell Metanephric Nephron Tubule Morphogenesis Urogenital System Development Histone Modification Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Chromatin Silencing At RDNA Phagocytosis, Recognition Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Negative Regulation Of Circadian Rhythm Regulation Of Branching Involved In Ureteric Bud Morphogenesis Chromatin Modification Histone H3-K9 Methylation Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Peptidyl-lysine Trimethylation Protein Hydroxylation Male Genitalia Development Metanephric Epithelium Development Macrophage Activation Tube Development Chromatin Organization Apoptotic Cell Clearance Metanephros Morphogenesis Chromatin Silencing Histone Demethylation Histone H3-K9 Modification Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Protein Demethylation Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Erythrocyte Development Bone Mineralization Peptidyl-amino Acid Modification Sprouting Angiogenesis	Apoptotic Process Programmed Cell Death Cell Death Death Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lgr4 lh named naturally newborn norrin rodent splice spondin spondins steroidogenic superovulated testicular tune wnt	abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Difference) ?		293t aquaporin bring cdnas conditioned conservation dependently ectodomain ed endogenously gonadal gonads intraperitoneal leucine lgr4 lh named naturally newborn norrin rodent splice spondin spondins steroidogenic superovulated testicular tune wnt	abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Intersection) ?