RSPO2 and JMJD6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		RSPO2	JMJD6
Description		R-spondin 2	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding BMP Receptor Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Canonical Wnt Signaling Pathway Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways		Regulation of FZD by ubiquitination	HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Brain morphology (MOSTest) ( 32665545) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 28196072 29146897) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		15 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837	30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		340419	23210
HPRD ID		17536	05371
Ensembl ID		ENSG00000147655	ENSG00000070495
Uniprot IDs		B3KVP3 Q6UXX9	B2WTI3 B2WTI4 Q6NYC1
PDB IDs		8XFP 8XFS 8XFT 8XUM 8Y69	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Semicircular Canal Formation Skin Epidermis Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation	Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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