RSPO2

Gene Name		R-spondin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Heparin Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)
Protein-protein Interactions		8 interactors: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 PLEKHF2 SUV39H1
Entrez ID		340419
HPRD ID		17536
Ensembl ID		ENSG00000147655
Uniprot IDs		B3KVP3 Q6UXX9
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Peptidyl-lysine Modification Rhythmic Process Kidney Development Histone H3-K9 Dimethylation Renal System Development Recognition Of Apoptotic Cell Metanephric Nephron Tubule Morphogenesis Urogenital System Development Histone Modification Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Chromatin Silencing At RDNA Phagocytosis, Recognition Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Negative Regulation Of Circadian Rhythm Regulation Of Branching Involved In Ureteric Bud Morphogenesis Chromatin Modification Histone H3-K9 Methylation Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Peptidyl-lysine Trimethylation Protein Hydroxylation Male Genitalia Development Metanephric Epithelium Development Macrophage Activation Tube Development Chromatin Organization Apoptotic Cell Clearance Metanephros Morphogenesis Chromatin Silencing Histone Demethylation Histone H3-K9 Modification Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Protein Demethylation Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Erythrocyte Development Bone Mineralization Peptidyl-amino Acid Modification Sprouting Angiogenesis
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