RSPO2 and KRTAP10-4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RSPO2	KRTAP10-4
Description		R-spondin 2	keratin associated protein 10-4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding BMP Receptor Binding	Protein Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Canonical Wnt Signaling Pathway Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination	Keratinization
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Brain morphology (MOSTest) ( 32665545) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 28196072 29146897) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Leukocyte telomere length ( 32109421)
Interacting Genes		15 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837	11 interacting genes: CATSPER1 E4F1 HOXA1 IGSF8 JOSD1 OTX1 RSPO2 WT1 ZNF32 ZNF625 ZSCAN26
Entrez ID		340419	386672
HPRD ID		17536	11190
Ensembl ID		ENSG00000147655	ENSG00000215454
Uniprot IDs		B3KVP3 Q6UXX9	P60372
PDB IDs		8XFP 8XFS 8XFT 8XUM 8Y69
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Semicircular Canal Formation Skin Epidermis Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Tube Morphogenesis Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Regulation Of Animal Organ Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Lung Growth Regulation Of RNA Metabolic Process Metencephalon Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Trachea Cartilage Morphogenesis Embryonic Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Branching Morphogenesis Of An Epithelial Tube Double-stranded Methylated DNA Binding S-shaped Body Morphogenesis Zinc Ion Binding Embryonic Neurocranium Morphogenesis Anterior/posterior Pattern Specification Diaphragm Development Regulation Of Female Gonad Development Morphogenesis Of A Branching Structure Positive Regulation Of Male Gonad Development Morphogenesis Of A Branching Epithelium Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Membrane Biogenesis CatSper Complex Outer Ear Morphogenesis
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