MT-CO1 and COX4I1

Number of citations of the paper that reports this interaction (PubMedID 14607829)
0

Data Source:
HPRD (in vivo)

		MT-CO1	COX4I1
Description		cytochrome c oxidase subunit I	cytochrome c oxidase subunit 4I1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding	Cytochrome-c Oxidase Activity Protein Binding
	Biological Process	Response To Hypoxia Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aerobic Respiration Cerebellum Development Respiratory Electron Transport Chain Cellular Respiration Response To Copper Ion Response To Electrical Stimulus Proton Transmembrane Transport	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Nutrient Cellular Respiration Proton Transmembrane Transport
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs		Cholic Acid N-Formylmethionine Oxygen	Cholic Acid N-Formylmethionine
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Leprosy ( 25642632) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		11 interacting genes: CDC42 CLEC4G COX4I1 COX5A DLG4 HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA	5 interacting genes: APP MT-CO1 SDCBP TRIM55 TRIM63
Entrez ID		4512	1327
HPRD ID		02469	00466
Ensembl ID		ENSG00000198804	ENSG00000131143
Uniprot IDs		P00395 U5YWV7	H3BNV9 P13073 Q86WV2
PDB IDs		5Z62	5Z62
Enriched GO Terms of Interacting Partners?		Dendritic Spine Morphogenesis Electron Transport Chain Respiratory Chain Complex IV Respiratory Electron Transport Chain Mitochondrial Electron Transport, Cytochrome C To Oxygen Cytochrome-c Oxidase Activity Response To Metal Ion Oxidative Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Dendritic Spine Organization Cellular Response To Metal Ion Positive Regulation Of Cellular Component Organization Neuron Projection Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Postsynapse P2Y1 Nucleotide Receptor Binding Establishment Of Integrated Proviral Latency JUN Phosphorylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Virus Coreceptor Activity Regulation Of Neuronal Synaptic Plasticity GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Mitochondrial Intermembrane Space Generation Of Precursor Metabolites And Energy Aerobic Electron Transport Chain Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Enzyme Activator Activity Establishment Of Viral Latency Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Periphery Endothelin Receptor Signaling Pathway Involved In Heart Process Aerobic Respiration Protein Phosphatase Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Trans-synaptic Signaling Synaptic Signaling DNA Ligase (ATP) Activity DNA Ligase IV Complex	Amyloid-beta Complex Response To Interleukin-1 Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Response To Copper Ion Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Frizzled Binding Response To Electrical Stimulus Interleukin-5 Receptor Complex Regulation Of Phosphorus Metabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Acetylcholine Receptor Activator Activity Innate Immune Response Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Generation Of Precursor Metabolites And Energy Interleukin-5 Receptor Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Defense Response To Symbiont Defense Response To Other Organism Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intracellular Signaling Cassette Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation
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