MT-CO1

Name	cytochrome c oxidase subunit I
Structure
Novel Interactors	1 novel interactors: MAPK8
Interactors	11 interactors: CDC42 CLEC4G COX4I1 COX5A DLG4 HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aerobic Respiration Cerebellum Development Respiratory Electron Transport Chain Cellular Respiration Response To Copper Ion Response To Electrical Stimulus Proton Transmembrane Transport
Pathways	Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs	Cholic Acid N-Formylmethionine Oxygen
Diseases	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS	No GWAS studies recorded
Entrez ID	4512
HPRD ID	02469
Ensembl ID	ENSG00000198804
Uniprot IDs	P00395 U5YWV7
PDB IDs	5Z62
GO Terms Enriched among Interactors ?	Dendritic Spine Morphogenesis Electron Transport Chain Respiratory Chain Complex IV Respiratory Electron Transport Chain Mitochondrial Electron Transport, Cytochrome C To Oxygen Cytochrome-c Oxidase Activity Response To Metal Ion Oxidative Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Dendritic Spine Organization Cellular Response To Metal Ion Positive Regulation Of Cellular Component Organization Neuron Projection Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Postsynapse P2Y1 Nucleotide Receptor Binding Establishment Of Integrated Proviral Latency JUN Phosphorylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Virus Coreceptor Activity Regulation Of Neuronal Synaptic Plasticity GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Mitochondrial Intermembrane Space Generation Of Precursor Metabolites And Energy Aerobic Electron Transport Chain Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Enzyme Activator Activity Establishment Of Viral Latency Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Periphery Endothelin Receptor Signaling Pathway Involved In Heart Process Aerobic Respiration Protein Phosphatase Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Trans-synaptic Signaling Synaptic Signaling DNA Ligase (ATP) Activity DNA Ligase IV Complex