COX1 and PRDX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		COX1	PRDX4
Gene Name		cytochrome c oxidase subunit I	peroxiredoxin 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity
	Biological Process		I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CDC42 CLEC4G COX4I1 COX5A KCNMB1 LIG4 MEOX2 PRDX4 SNCA	24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN
Entrez ID		4512	10549
HPRD ID		02469	05935
Ensembl ID			ENSG00000123131
Uniprot IDs		P00395 Q7GXY8	Q13162
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS
Enriched GO Terms of Interacting Partners?		Respiratory Electron Transport Chain Electron Transport Chain Cellular Respiration Monovalent Inorganic Cation Transport Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Energy Derivation By Oxidation Of Organic Compounds Response To Metal Ion Neuron Death Generation Of Precursor Metabolites And Energy Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Male Germ Cell Proliferation DNA Ligation Involved In DNA Recombination Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Cation Transport Response To Inorganic Substance Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hair Follicle Cell Proliferation Cellular Response To Metal Ion Negative Regulation Of Protein Complex Assembly Oxidation-reduction Process Regulation Of Protein Stability Cellular Response To Inorganic Substance Regulation Of Male Germ Cell Proliferation Negative Regulation Of Dopamine Metabolic Process Submandibular Salivary Gland Formation Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Actin Filament Branching Negative Regulation Of Cellular Respiration Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Microtubule-based Process Negative Regulation Of Neuron Apoptotic Process Hydrogen Ion Transmembrane Transport Ion Transport Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Golgi Localization Response To Iron(II) Ion Cellular Response To Copper Ion Somite Specification	Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels
Tagcloud ?		adipogenic assessments cd105 cd73 cd90 chondrogenic derangement fetal galactosidase gdm gestation gestational huc immunoblotting intriguing jelly msc mscs nd2 nd9 osteogenic pgc programming senescence tfam uc umbilical underscore wharton	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Difference) ?		adipogenic assessments cd105 cd73 cd90 chondrogenic derangement fetal galactosidase gdm gestation gestational huc immunoblotting intriguing jelly msc mscs nd2 nd9 osteogenic pgc programming senescence tfam uc umbilical underscore wharton	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Intersection) ?