MT-CO1 and KCNMB1

Number of citations: 0 (PubMedID 16002321)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		MT-CO1	KCNMB1
Name		cytochrome c oxidase subunit I	potassium calcium-activated channel subfamily M regulatory beta subunit 1
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity
	Biological Process	Response To Hypoxia Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aerobic Respiration Cerebellum Development Respiratory Electron Transport Chain Cellular Respiration Response To Copper Ion Response To Electrical Stimulus Proton Transmembrane Transport	Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs		Cholic Acid N-Formylmethionine Oxygen	Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)	None
GWAS		No GWAS studies recorded	Acne (severe) ( 24927181 ) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025 )
Novel Interactors		1 novel interactors: MAPK8	None recorded
Interacting Genes		11 interacting genes: CDC42 CLEC4G COX4I1 COX5A DLG4 HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA	5 interacting genes: CLCA1 EWSR1 KCNMA1 MT-CO1 STX8
Entrez ID		4512	3779
HPRD ID		02469	10358
Ensembl ID		ENSG00000198804	ENSG00000145936
Uniprot IDs		P00395 U5YWV7	Q16558
PDB IDs		5Z62	Not available
GO Terms Enriched among Interactors		Dendritic Spine Morphogenesis Electron Transport Chain Respiratory Chain Complex IV Respiratory Electron Transport Chain Mitochondrial Electron Transport, Cytochrome C To Oxygen Cytochrome-c Oxidase Activity Response To Metal Ion Oxidative Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Dendritic Spine Organization Cellular Response To Metal Ion Positive Regulation Of Cellular Component Organization Neuron Projection Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Postsynapse P2Y1 Nucleotide Receptor Binding Establishment Of Integrated Proviral Latency JUN Phosphorylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Virus Coreceptor Activity Regulation Of Neuronal Synaptic Plasticity GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Mitochondrial Intermembrane Space Generation Of Precursor Metabolites And Energy Aerobic Electron Transport Chain Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Enzyme Activator Activity Establishment Of Viral Latency Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Periphery Endothelin Receptor Signaling Pathway Involved In Heart Process Aerobic Respiration Protein Phosphatase Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Trans-synaptic Signaling Synaptic Signaling DNA Ligase (ATP) Activity DNA Ligase IV Complex	Response To Decreased Oxygen Levels Response To Oxygen Levels Response To Hypoxia Large Conductance Calcium-activated Potassium Channel Activity Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Monoatomic Ion Transport Negative Regulation Of Cell Volume Chloride Channel Inhibitor Activity Urinary Bladder Smooth Muscle Contraction Transmembrane Transport Calcium-activated Potassium Channel Activity Response To Metal Ion Cytochrome-c Oxidase Activity Intracellularly Calcium-gated Chloride Channel Activity Zymogen Granule Membrane Mitochondrial Electron Transport, Cytochrome C To Oxygen Intracellular Potassium Ion Homeostasis Respiratory Chain Complex IV Oxidative Phosphorylation Early Endosome To Late Endosome Transport