LGALS1 and ITGB1

Number of citations of the paper that reports this interaction (PMID 14550305)
15

Data Source:
HPRD (in vitro)

		LGALS1	ITGB1
Gene Name		lectin, galactoside-binding, soluble, 1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Cell Surface Extracellular Matrix Extracellular Vesicular Exosome	Acrosomal Vesicle Ruffle Basement Membrane Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Hemidesmosome Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Recycling Endosome Extracellular Vesicular Exosome Invadopodium Membrane Synaptic Membrane
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Binding Galactoside Binding Lactose Binding Protein Homodimerization Activity Laminin Binding Poly(A) RNA Binding	Virus Receptor Activity Glycoprotein Binding Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Peptide Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Alpha-actinin Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development T Cell Costimulation Multicellular Organismal Response To Stress Positive Regulation Of Erythrocyte Aggregation Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Myoblast Differentiation Response To Axon Injury Cellular Response To Glucose Stimulus Cellular Response To Organic Cyclic Compound	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Cell Fate Specification Tissue Homeostasis Cell Migration Involved In Sprouting Angiogenesis Cellular Calcium Ion Homeostasis Cellular Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Response To Virus Regulation Of Collagen Catabolic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Activity Viral Process Cell Migration Formation Of Radial Glial Scaffolds B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Projection Organization Cell-substrate Adhesion Protein Transport Within Lipid Bilayer Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Cell Junction Assembly Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Response To Drug Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAPK Cascade Sarcomere Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Maternal Process Involved In Female Pregnancy Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Vitamin D Cellular Response To Ionizing Radiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis
Pathways			Platelet Adhesion to exposed collagen Axon guidance Elastic fibre formation L1CAM interactions Molecules associated with elastic fibres Laminin interactions ECM proteoglycans Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell junction organization Signal transduction by L1 Semaphorin interactions Other semaphorin interactions Non-integrin membrane-ECM interactions Basigin interactions Cell surface interactions at the vascular wall Syndecan interactions CHL1 interactions Integrin cell surface interactions Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		14 interactors: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS ITGB1 LGALS3BP MUC16 PTPRC SPN USP4 VPREB1	67 interactors: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EPS8 FBLN1 FBXO2 FHL2 FLNA FLNB FLT4 FN1 GNB2L1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 NCKIPSD NF2 NME1 NMRK2 PDHB PLAUR PRKCA PRKCE PTK2 PXN RAB25 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		3956	3688
HPRD ID		01040	00628
Ensembl ID		ENSG00000100097	ENSG00000150093
Uniprot IDs		P09382	P05556
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Lymphocyte Activation Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Activation Regulation Of Immune System Process Leukocyte Migration Defense Response Regulation Of Immune Response Lymphocyte Differentiation Heterotypic Cell-cell Adhesion Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Hemopoiesis Immune System Development Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Regulation Of Cell-cell Adhesion T Cell Differentiation Regulation Of Lymphocyte Activation Locomotion T Cell Selection Blood Coagulation Positive Regulation Of Intracellular Signal Transduction Hemostasis Cell Migration Positive Regulation Of Phosphorylation Cellular Defense Response Regulation Of Cell Activation Visual Learning Positive Regulation Of T Cell Activation Cell Motility Positive Regulation Of Protein Modification Process Visual Behavior Positive Regulation Of Homotypic Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Body Fluid Levels Associative Learning Regulation Of Protein Phosphorylation	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell-matrix Adhesion Cell-substrate Adhesion Wound Healing Response To Wounding Regulation Of Body Fluid Levels Multicellular Organismal Development Movement Of Cell Or Subcellular Component Anatomical Structure Development Locomotion System Development Developmental Process Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Cell Migration Leukocyte Migration Cell Motility Signal Transduction Cell Junction Assembly Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signaling Response To Stimulus Positive Regulation Of Locomotion Regulation Of Cell Motility Cell Communication Cell Activation Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Platelet Activation Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Process Cell Morphogenesis Response To Stress
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?