LGALS1 and CD2

Number of citations of the paper that reports this interaction (PMID 10642604)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LGALS1	CD2
Gene Name		lectin, galactoside-binding, soluble, 1	CD2 molecule
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Cell Surface Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Binding Galactoside Binding Lactose Binding Protein Homodimerization Activity Laminin Binding Poly(A) RNA Binding	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development T Cell Costimulation Multicellular Organismal Response To Stress Positive Regulation Of Erythrocyte Aggregation Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Myoblast Differentiation Response To Axon Injury Cellular Response To Glucose Stimulus Cellular Response To Organic Cyclic Compound	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways			Cell surface interactions at the vascular wall
Drugs			Alefacept Alpha-D-Mannose
Diseases
GWAS		Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		14 interactors: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS ITGB1 LGALS3BP MUC16 PTPRC SPN USP4 VPREB1	19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1
Entrez ID		3956	914
HPRD ID		01040	01750
Ensembl ID		ENSG00000100097	ENSG00000116824
Uniprot IDs		P09382	P06729 Q53F96
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Lymphocyte Activation Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Activation Regulation Of Immune System Process Leukocyte Migration Defense Response Regulation Of Immune Response Lymphocyte Differentiation Heterotypic Cell-cell Adhesion Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Hemopoiesis Immune System Development Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Regulation Of Cell-cell Adhesion T Cell Differentiation Regulation Of Lymphocyte Activation Locomotion T Cell Selection Blood Coagulation Positive Regulation Of Intracellular Signal Transduction Hemostasis Cell Migration Positive Regulation Of Phosphorylation Cellular Defense Response Regulation Of Cell Activation Visual Learning Positive Regulation Of T Cell Activation Cell Motility Positive Regulation Of Protein Modification Process Visual Behavior Positive Regulation Of Homotypic Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Body Fluid Levels Associative Learning Regulation Of Protein Phosphorylation	Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Intersection) ?