LGALS1 and MUC16

Number of citations of the paper that reports this interaction (PubMedID 12615972)
0

Data Source:
HPRD (in vivo, in vitro)

		LGALS1	MUC16
Description		galectin 1	mucin 16, cell surface associated
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Extracellular Matrix Extracellular Exosome Galectin Complex	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Membrane Vesicle Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Carbohydrate Binding Lactose Binding Laminin Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction T Cell Costimulation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Myoblast Differentiation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Inflammatory Response Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Dendritic Cell Differentiation	Cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol OTX-008	Dimethyl sulfoxide Oregovomab
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 (CA 125) levels ( 31666285) Tourette syndrome ( 30818990)
Interacting Genes		17 interacting genes: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS HSPB2 ITGB1 LGALS3BP MUC16 NLGN3 PTEN PTPRC SPN USP4 VPREB1	3 interacting genes: LGALS1 MSLN UBC
Entrez ID		3956	94025
HPRD ID		01040	07548
Ensembl ID		ENSG00000100097	ENSG00000181143
Uniprot IDs		A0A384MR27 P09382	A0AAG2UXK0 B3KY81 Q8WXI7
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z 8OJP 8R74 8RDC	7SA9 8GKL 8VM1 8VRS
Enriched GO Terms of Interacting Partners?		External Side Of Plasma Membrane Lymphocyte Activation T Cell Activation Leukocyte Activation Cell Adhesion Cell Activation Immune System Process T Cell Selection Rhythmic Synaptic Transmission Signaling Receptor Activity Heterotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Mononuclear Cell Differentiation Positive Regulation Of Cell Population Proliferation Cellular Defense Response Membrane Raft Distribution Cell Surface Membrane Raft Localization Leukocyte Differentiation Coreceptor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Presynaptic Membrane Assembly Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Presynaptic Membrane Organization Regulation Of Adaptive Immune Response Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of Signal Transduction Negative T Cell Selection Regulation Of Cytokine Production Cell-cell Adhesion Immune Response Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Lymphocyte Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Mediated Immunity Dendritic Spine Morphogenesis Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of T Cell Proliferation T Cell Receptor Complex T Cell Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production	Lactose Binding Positive Regulation Of Dendritic Cell Differentiation Galectin Complex Negative Regulation Of T-helper 17 Cell Lineage Commitment Plasma Cell Differentiation Nuclear Migration Along Microfilament Microtubule-based Transport Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Determination Of Heart Left/right Asymmetry Outer Dynein Arm Docking Complex
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