LGALS1 and CD8A

Number of citations of the paper that reports this interaction (PubMedID 10490978)
0

Data Source:
HPRD (in vitro)

		LGALS1	CD8A
Description		galectin 1	CD8 subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Extracellular Matrix Extracellular Exosome Galectin Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane T Cell Receptor Complex Receptor Complex Plasma Membrane Raft
	Molecular Function	RNA Binding Protein Binding Carbohydrate Binding Lactose Binding Laminin Binding Receptor Ligand Activity	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction T Cell Costimulation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Myoblast Differentiation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Inflammatory Response Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Dendritic Cell Differentiation	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation T Cell Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol OTX-008
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Fat distribution (HIV) ( 21897333)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS HSPB2 ITGB1 LGALS3BP MUC16 NLGN3 PTEN PTPRC SPN USP4 VPREB1	17 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		3956	925
HPRD ID		01040	01737
Ensembl ID		ENSG00000100097	ENSG00000153563
Uniprot IDs		A0A384MR27 P09382	P01732 Q6ZVS2 Q8TAW8
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z 8OJP 8R74 8RDC	1AKJ 1CD8 1Q69 2HP4 3QZW 7UMG 7UVF 8EW6
Enriched GO Terms of Interacting Partners?		External Side Of Plasma Membrane Lymphocyte Activation T Cell Activation Leukocyte Activation Cell Adhesion Cell Activation Immune System Process T Cell Selection Rhythmic Synaptic Transmission Signaling Receptor Activity Heterotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Mononuclear Cell Differentiation Positive Regulation Of Cell Population Proliferation Cellular Defense Response Membrane Raft Distribution Cell Surface Membrane Raft Localization Leukocyte Differentiation Coreceptor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Presynaptic Membrane Assembly Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Presynaptic Membrane Organization Regulation Of Adaptive Immune Response Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of Signal Transduction Negative T Cell Selection Regulation Of Cytokine Production Cell-cell Adhesion Immune Response Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Lymphocyte Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Mediated Immunity Dendritic Spine Morphogenesis Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of T Cell Proliferation T Cell Receptor Complex T Cell Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production	MHC Class I Protein Complex Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I ER To Golgi Transport Vesicle Membrane Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Adaptive Immune Response Regulation Of T Cell Mediated Immunity Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains External Side Of Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Lumenal Side Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Lymphocyte Activation Regulation Of Immune System Process T Cell Activation Antigen Processing And Presentation Recycling Endosome Membrane Regulation Of Lymphocyte Mediated Immunity TAP Binding Early Endosome Membrane T Cell Receptor Signaling Pathway Negative Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Immune System Process Regulation Of T Cell Activation CD8 Receptor Binding Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway
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