ALDOA and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (in vitro)

		ALDOA	MYOC
Gene Name		aldolase A, fructose-bisphosphate	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Identical Protein Binding Poly(A) RNA Binding Fructose Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Platelet Degranulation Carbohydrate Metabolic Process Fructose Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Blood Coagulation Regulation Of Cell Shape Pathogenesis Platelet Activation Fructose 1,6-bisphosphate Metabolic Process Small Molecule Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Glycolysis Platelet degranulation Platelet activation, signaling and aggregation Metabolism of carbohydrates
Drugs		1,6-Fructose Diphosphate (Linear Form) 1,3-Dihydroxyacetonephosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ADRB2 ALDOB ALDOC ATP6V1E1 BCAT2 CACNA1A DYNLL1 EGFR FANCA GALNT6 GPD2 IFNA4 MLH1 MYOC PCNA PIAS4 PLD2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		226	4653
HPRD ID		00070	03387
Ensembl ID		ENSG00000149925	ENSG00000034971
Uniprot IDs		P04075	Q99972
PDB IDs		1ALD 2ALD 4ALD
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Fructose 1,6-bisphosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Cellular Component Assembly Skeletal Muscle Adaptation Hexose Metabolic Process Monosaccharide Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stimulus Fructose Metabolic Process Catabolic Process Cell Cycle G2/M Transition Of Mitotic Cell Cycle Homeostatic Process Organ Development Regulation Of DNA Replication Cellular Protein Complex Assembly Protein Sumoylation Cell Cycle Process Carbohydrate Catabolic Process Mitotic Cell Cycle Process Cellular Response To Dexamethasone Stimulus Carbohydrate Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Developmental Process Response To Dexamethasone Cellular Metabolic Process Mitotic Cell Cycle Response To Stress System Development Salivary Gland Morphogenesis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Vasodilation Salivary Gland Development Metal Ion Homeostasis Positive Regulation Of Signal Transduction Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?