ALDOA and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 22496890)
28

Data Source:
BioGRID (two hybrid)

		ALDOA	HSD17B10
Description		aldolase, fructose-bisphosphate A	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex
	Molecular Function	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Lyase Activity Identical Protein Binding Cadherin Binding Fructose Binding	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Fructose Metabolic Process Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation
Drugs		Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		37 interacting genes: ADRB2 ATP6V1E1 BCAT2 CACNA1A CEBPA CYTH2 DSCR9 DYNLL1 ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LCOR LINC01554 MLH1 MYOC NXF1 OGT PCNA PIAS4 PLD2 SHANK3 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	30 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		226	3028
HPRD ID		00070	02223
Ensembl ID		ENSG00000149925	ENSG00000072506
Uniprot IDs		P04075 V9HWN7	A0A0S2Z410 Q99714
PDB IDs		1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO	1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB3:ERBB2 Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Basal Plasma Membrane Neuregulin Receptor Activity Negative Regulation Of DNA Metabolic Process ERBB Signaling Pathway Isoleucine Metabolic Process L-isoleucine Catabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Adaptation Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation ERBB4 Signaling Pathway Telomere Localization Gluconeogenesis Hexose Biosynthetic Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of DNA Metabolic Process Receptor Complex Regulation Of Purine Nucleotide Metabolic Process Canonical Glycolysis Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of DNA Biosynthetic Process Dopamine Transport Brown Fat Cell Differentiation Positive Regulation Of Excitatory Postsynaptic Potential Import Into Cell Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Protein-containing Complex Binding Positive Regulation Of Mini Excitatory Postsynaptic Potential Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycolytic Process Through Glucose-6-phosphate M Band Nicotinamide Nucleotide Metabolic Process	Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process
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