ALDOA and ADRB2

Number of citations of the paper that reports this interaction (PMID 24561123)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		ALDOA	ADRB2
Gene Name		aldolase A, fructose-bisphosphate	adrenoceptor beta 2, surface
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Extracellular Vesicular Exosome	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Identical Protein Binding Poly(A) RNA Binding Fructose Binding	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding
	Biological Process	Platelet Degranulation Carbohydrate Metabolic Process Fructose Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Blood Coagulation Regulation Of Cell Shape Pathogenesis Platelet Activation Fructose 1,6-bisphosphate Metabolic Process Small Molecule Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Glycolysis Platelet degranulation Platelet activation, signaling and aggregation Metabolism of carbohydrates	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		1,6-Fructose Diphosphate (Linear Form) 1,3-Dihydroxyacetonephosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE	Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ADRB2 ALDOB ALDOC ATP6V1E1 BCAT2 CACNA1A DYNLL1 EGFR FANCA GALNT6 GPD2 IFNA4 MLH1 MYOC PCNA PIAS4 PLD2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		226	154
HPRD ID		00070	00187
Ensembl ID		ENSG00000149925	ENSG00000169252
Uniprot IDs		P04075	P07550
PDB IDs		1ALD 2ALD 4ALD	1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Fructose 1,6-bisphosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Cellular Component Assembly Skeletal Muscle Adaptation Hexose Metabolic Process Monosaccharide Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stimulus Fructose Metabolic Process Catabolic Process Cell Cycle G2/M Transition Of Mitotic Cell Cycle Homeostatic Process Organ Development Regulation Of DNA Replication Cellular Protein Complex Assembly Protein Sumoylation Cell Cycle Process Carbohydrate Catabolic Process Mitotic Cell Cycle Process Cellular Response To Dexamethasone Stimulus Carbohydrate Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Developmental Process Response To Dexamethasone Cellular Metabolic Process Mitotic Cell Cycle Response To Stress System Development Salivary Gland Morphogenesis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Vasodilation Salivary Gland Development Metal Ion Homeostasis Positive Regulation Of Signal Transduction Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Difference) ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
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