ALDOA and GALNT6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALDOA	GALNT6
Description		aldolase, fructose-bisphosphate A	polypeptide N-acetylgalactosaminyltransferase 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Golgi Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Lyase Activity Identical Protein Binding Cadherin Binding Fructose Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Fructose Metabolic Process Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	O-linked glycosylation of mucins
Drugs		Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Fruit consumption ( 32066663) Keratoconus ( 33649486) Low density lipoprotein cholesterol levels ( 32154731) Nicotine dependence symptom count ( 25555482)
Interacting Genes		37 interacting genes: ADRB2 ATP6V1E1 BCAT2 CACNA1A CEBPA CYTH2 DSCR9 DYNLL1 ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LCOR LINC01554 MLH1 MYOC NXF1 OGT PCNA PIAS4 PLD2 SHANK3 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	8 interacting genes: ALDOA FN1 GOLPH3 GOLPH3L LGALS3BP SLC5A6 TAF9 TMEM9
Entrez ID		226	11226
HPRD ID		00070	05512
Ensembl ID		ENSG00000149925	ENSG00000139629
Uniprot IDs		P04075 V9HWN7	Q8NCL4
PDB IDs		1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB3:ERBB2 Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Basal Plasma Membrane Neuregulin Receptor Activity Negative Regulation Of DNA Metabolic Process ERBB Signaling Pathway Isoleucine Metabolic Process L-isoleucine Catabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Adaptation Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation ERBB4 Signaling Pathway Telomere Localization Gluconeogenesis Hexose Biosynthetic Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of DNA Metabolic Process Receptor Complex Regulation Of Purine Nucleotide Metabolic Process Canonical Glycolysis Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of DNA Biosynthetic Process Dopamine Transport Brown Fat Cell Differentiation Positive Regulation Of Excitatory Postsynaptic Potential Import Into Cell Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Protein-containing Complex Binding Positive Regulation Of Mini Excitatory Postsynaptic Potential Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycolytic Process Through Glucose-6-phosphate M Band Nicotinamide Nucleotide Metabolic Process	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Platelet Alpha Granule Lumen Sodium-dependent Multivitamin Transmembrane Transporter Activity Pantothenate:sodium Symporter Activity Pantothenate Transmembrane Transport Pantothenate Transmembrane Transporter Activity Golgi Cisterna Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Fructose-bisphosphate Aldolase Activity Negative Regulation Of Monocyte Activation Blood Microparticle Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Biotin Transmembrane Transporter Activity Iodide Transmembrane Transport Monocarboxylate:sodium Symporter Activity Biotin Import Across Plasma Membrane Amide Transmembrane Transporter Activity Biotin Transport Sulfur Compound Transmembrane Transporter Activity Golgi Organization Post-Golgi Vesicle-mediated Transport Asymmetric Golgi Ribbon Formation Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein-containing Complex Assembly Regulation Of Cell Shape Calcium-independent Cell-matrix Adhesion Iodide Transmembrane Transporter Activity Biotin Metabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein Retention In Golgi Apparatus Positive Regulation Of Protein Secretion Cellular Component Assembly Protein-containing Complex Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Vitamin Transmembrane Transporter Activity Response To Rapamycin Fructose Binding Pre-snoRNP Complex Iodide Transport Protein Localization To Plasma Membrane Trans-Golgi Network
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