PCBD2 and HES4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PCBD2	HES4
Gene Name		pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	hes family bHLH transcription factor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Mitochondrion	Nucleus
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity	DNA Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 18391951)
Protein-Protein Interactions		31 interactors: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	5 interactors: COPG2 LTN1 PCBD1 PCBD2 RGS3
Entrez ID		84105	57801
HPRD ID		17824	16273
Ensembl ID			ENSG00000188290
Uniprot IDs		Q9H0N5	D6REB3 E9PB28 Q9HCC6
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Negative Regulation Of Gene Expression Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Cell Death Death Stem Cell Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Histone Modification Negative Regulation Of Cell Differentiation Stem Cell Development Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation	Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Pteridine-containing Compound Metabolic Process Protein Homotetramerization Protein Tetramerization Protein Heterooligomerization Coenzyme Biosynthetic Process Protein Homooligomerization Cofactor Metabolic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Protein Oligomerization Regulation Of Protein Homodimerization Activity
Tagcloud ?			brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Difference) ?			brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Intersection) ?