PCBD2 and MED30

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PCBD2	MED30
Gene Name		pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	mediator complex subunit 30
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Mitochondrion	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 18391951)	Kawasaki disease ( 22446961)
Protein-Protein Interactions		31 interactors: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	13 interactors: APP DOCK8 KRTAP10-9 MED17 MED22 MED27 MED28 MED4 MED8 MED9 MTA2 PCBD2 SS18L1
Entrez ID		84105	90390
HPRD ID		17824	11631
Ensembl ID			ENSG00000164758
Uniprot IDs		Q9H0N5	Q96HR3
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Negative Regulation Of Gene Expression Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Cell Death Death Stem Cell Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Histone Modification Negative Regulation Of Cell Differentiation Stem Cell Development Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process DNA-templated Transcription, Initiation Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Stem Cell Maintenance Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Stem Cell Development Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Stem Cell Differentiation Positive Regulation Of Metabolic Process Memory T Cell Proliferation Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Cell Development Collateral Sprouting In Absence Of Injury Cell Recognition Dendrite Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Smooth Muscle Cell Differentiation
Tagcloud ?			abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med24 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Difference) ?			abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med24 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Intersection) ?