GUCY1A2 and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		GUCY1A2	SNTA1
Description		guanylate cyclase 1 soluble subunit alpha 2	syntrophin alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Nitric Oxide Mediated Signal Transduction Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Response To Oxygen Levels	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Isosorbide Plecanatide
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		2977	6640
HPRD ID		03146	03009
Ensembl ID		ENSG00000152402	ENSG00000101400
Uniprot IDs		P33402	B3KTR0 Q13424
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Kinase Binding Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Protein Localization To Cell Junction Postsynaptic Density Membrane Adherens Junction Glutamatergic Synapse Basolateral Plasma Membrane GMP Kinase Activity Chemical Synaptic Transmission GDP Metabolic Process Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Juxtaparanode Region Of Axon Synaptic Signaling Cellular Response To Potassium Ion Cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Response To Potassium Ion Protein Kinase Binding Cell-cell Adhesion AMPA Glutamate Receptor Complex GMP Metabolic Process Localization Within Membrane Protein Localization To Postsynaptic Membrane Regulation Of System Process Cell Junction Protein Localization To Postsynapse Nervous System Development Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Signaling Hsp90 Protein Binding Cell Communication Postsynaptic Density Regulation Of Blood Circulation Phosphatase Binding Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process System Process Ribose Phosphate Metabolic Process	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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