GUCY1A2

Name	guanylate cyclase 1 soluble subunit alpha 2
Structure	No pdb structure
Interactors	9 interactors: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1
GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Nitric Oxide Mediated Signal Transduction Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Response To Oxygen Levels
Pathways	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs	Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Isosorbide Plecanatide
GWAS	Anxiety disorder ( 25390645 ) Colorectal or endometrial cancer ( 26621817 ) Diastolic blood pressure ( 27841878 ) Obesity-related traits ( 23251661 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Upper eyelid morphology ( 29921221 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 ) Whole brain grey matter density ( 31530798 )
Entrez ID	2977
HPRD ID	03146
Ensembl ID	ENSG00000152402
Uniprot IDs	P33402
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Kinase Binding Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Protein Localization To Cell Junction Postsynaptic Density Membrane Adherens Junction Glutamatergic Synapse Basolateral Plasma Membrane GMP Kinase Activity Chemical Synaptic Transmission GDP Metabolic Process Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Juxtaparanode Region Of Axon Synaptic Signaling Cellular Response To Potassium Ion Cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Response To Potassium Ion Protein Kinase Binding Cell-cell Adhesion AMPA Glutamate Receptor Complex GMP Metabolic Process Localization Within Membrane Protein Localization To Postsynaptic Membrane Regulation Of System Process Cell Junction Protein Localization To Postsynapse Nervous System Development Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Signaling Hsp90 Protein Binding Cell Communication Postsynaptic Density Regulation Of Blood Circulation Phosphatase Binding Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process System Process Ribose Phosphate Metabolic Process