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GUCY1A2 and STUB1
Number of citations of the paper that reports this interaction (PubMedID
17873020
)
0
Data Source:
BioGRID
(enzymatic study)
GUCY1A2
STUB1
Description
guanylate cyclase 1 soluble subunit alpha 2
STIP1 homology and U-box containing protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Guanylate Cyclase Complex, Soluble
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Protein Folding Chaperone Complex
Molecular Function
Nucleotide Binding
Guanylate Cyclase Activity
Protein Binding
GTP Binding
Lyase Activity
Phosphorus-oxygen Lyase Activity
Heme Binding
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
R-SMAD Binding
Biological Process
CGMP Biosynthetic Process
Signal Transduction
Nitric Oxide Mediated Signal Transduction
Cyclic Nucleotide Biosynthetic Process
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
CGMP-mediated Signaling
Intracellular Signal Transduction
Response To Oxygen Levels
MAPK Cascade
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Signal Transduction
Positive Regulation Of Metabolic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Protein Ubiquitination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
ERAD Pathway
ERBB2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Stabilization
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Mitophagy
Positive Regulation Of ERAD Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Pathways
Nitric oxide stimulates guanylate cyclase
Smooth Muscle Contraction
Smooth Muscle Contraction
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Nitric Oxide
Isosorbide mononitrate
Riociguat
Methylene blue
Molsidomine
Isosorbide
Plecanatide
Diseases
GWAS
Anxiety disorder (
25390645
)
Colorectal or endometrial cancer (
26621817
)
Diastolic blood pressure (
27841878
)
Obesity-related traits (
23251661
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Upper eyelid morphology (
29921221
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Whole brain grey matter density (
31530798
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
9 interacting genes:
DLG1
DLG2
DLG3
DLG4
ERBIN
GSC2
GUCY1B1
SNTA1
STUB1
149 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BBOX1
BCR
BMPR1B
CASP6
CCL28
CDK4
CDK9
CDKN1A
CFTR
CIP2A
CRIP1
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EGFR
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HMGB1
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
HUNK
INSR
JAK1
JOSD1
JOSD2
KHDRBS1
KPNA2
LRRK1
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
METTL14
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PKM
PLK1
PMAIP1
POLB
POT1
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
RAF1
RFFL
RGS17
RHBDF2
RUNX1
RUNX2
RUSC1
S100A2
S100P
SIRT6
SLC7A11-AS1
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNCA
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP63
TP73
TPD52
TRAF6
TTN
TXN2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
UNC45B
VCP
VDAC1
XIAP
YTHDF2
Entrez ID
2977
10273
HPRD ID
03146
06232
Ensembl ID
ENSG00000152402
ENSG00000103266
Uniprot IDs
P33402
Q9UNE7
PDB IDs
4KBQ
6EFK
6NSV
7TB1
8EHZ
8EI0
8F14
8F15
8F16
8F17
8FYU
8GCK
8SUV
9DRY
Enriched GO Terms of Interacting Partners
?
Neuromuscular Junction
Establishment Or Maintenance Of Apical/basal Cell Polarity
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Kinase Binding
Ionotropic Glutamate Receptor Binding
Receptor Localization To Synapse
Receptor Clustering
Establishment Or Maintenance Of Cell Polarity
Protein Localization To Synapse
Protein Localization To Cell Junction
Postsynaptic Density Membrane
Adherens Junction
Glutamatergic Synapse
Basolateral Plasma Membrane
GMP Kinase Activity
Chemical Synaptic Transmission
GDP Metabolic Process
Protein Localization To Membrane
Neuron Projection
Trans-synaptic Signaling
Juxtaparanode Region Of Axon
Synaptic Signaling
Cellular Response To Potassium Ion
Cell Adhesion
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Biological Quality
Response To Potassium Ion
Protein Kinase Binding
Cell-cell Adhesion
AMPA Glutamate Receptor Complex
GMP Metabolic Process
Localization Within Membrane
Protein Localization To Postsynaptic Membrane
Regulation Of System Process
Cell Junction
Protein Localization To Postsynapse
Nervous System Development
Cell-cell Signaling
Regulation Of Sodium Ion Transmembrane Transport
Signaling
Hsp90 Protein Binding
Cell Communication
Postsynaptic Density
Regulation Of Blood Circulation
Phosphatase Binding
Purine Ribonucleotide Metabolic Process
Ribonucleotide Metabolic Process
System Process
Ribose Phosphate Metabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Intracellular Signal Transduction
Cytosol
Regulation Of Primary Metabolic Process
Enzyme Binding
Positive Regulation Of Macromolecule Metabolic Process
ATP Binding
Nucleus
Cytoplasm
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Stress
Cellular Response To Stress
Proteasomal Protein Catabolic Process
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Tagcloud (Intersection)
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