GUCY1A2 and DLG3

Number of citations of the paper that reports this interaction (PMID 11572861)
28

Data Source:
HPRD (in vitro)

		GUCY1A2	DLG3
Gene Name		guanylate cyclase 1, soluble, alpha 2	discs, large homolog 3 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane
	Molecular Function	Guanylate Cyclase Activity GTP Binding Heme Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Blood Coagulation Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase	Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		8 interactors: DLG1 DLG2 DLG3 DLG4 ERBB2IP GUCY1B3 SNTA1 STUB1	40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		2977	1741
HPRD ID		03146	02177
Ensembl ID		ENSG00000152402	ENSG00000082458
Uniprot IDs		B7ZLT5 P33402	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Organophosphate Metabolic Process Synaptic Transmission Cellular Protein Localization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Organization Cell-cell Signaling Protein Localization Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Dephosphorylation Axon Guidance Signaling Regulation Of Ion Transmembrane Transport Cell Communication Regulation Of Vasoconstriction By Circulating Norepinephrine Small Molecule Metabolic Process Regulation Of Catalytic Activity Cellular Localization Regulation Of Phosphatase Activity Axonogenesis Positive Regulation Of Chaperone-mediated Protein Complex Assembly Basal Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Dephosphorylation Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Phosphate-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Synapse Organization Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production	Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization
Tagcloud ?			17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?			17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?