GUCY1A2 and GUCY1B3

Number of citations of the paper that reports this interaction (PMID 11572861)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GUCY1A2	GUCY1B3
Gene Name		guanylate cyclase 1, soluble, alpha 2	guanylate cyclase 1, soluble, beta 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Guanylate Cyclase Complex, Soluble Intracellular Membrane-bounded Organelle
	Molecular Function	Guanylate Cyclase Activity GTP Binding Heme Binding	Guanylate Cyclase Activity Receptor Activity GTP Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity Hsp90 Protein Binding
	Biological Process	CGMP Biosynthetic Process Signal Transduction Blood Coagulation Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Coagulation Blood Circulation
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase	Platelet homeostasis Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		8 interactors: DLG1 DLG2 DLG3 DLG4 ERBB2IP GUCY1B3 SNTA1 STUB1	4 interactors: AGAP1 APP GUCY1A2 HSP90AA1
Entrez ID		2977	2983
HPRD ID		03146	00769
Ensembl ID		ENSG00000152402	ENSG00000061918
Uniprot IDs		B7ZLT5 P33402	D6RC99 E9PCN2 Q02153
PDB IDs			2WZ1 3UVJ
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Organophosphate Metabolic Process Synaptic Transmission Cellular Protein Localization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Organization Cell-cell Signaling Protein Localization Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Dephosphorylation Axon Guidance Signaling Regulation Of Ion Transmembrane Transport Cell Communication Regulation Of Vasoconstriction By Circulating Norepinephrine Small Molecule Metabolic Process Regulation Of Catalytic Activity Cellular Localization Regulation Of Phosphatase Activity Axonogenesis Positive Regulation Of Chaperone-mediated Protein Complex Assembly Basal Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Dephosphorylation Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Phosphate-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Synapse Organization Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production	Synaptic Growth At Neuromuscular Junction Positive Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Protein Import Into Mitochondrial Outer Membrane Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cellular Biosynthetic Process Neuron Remodeling Axon Guidance Blood Coagulation Hemostasis Chaperone-mediated Protein Complex Assembly Signal Transduction Axonogenesis Positive Regulation Of CGMP Biosynthetic Process Cellular Copper Ion Homeostasis Positive Regulation Of CGMP Metabolic Process Signaling CGMP Biosynthetic Process Protein Refolding Axon Development Regulation Of Body Fluid Levels Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Small Molecule Metabolic Process Wound Healing Chemotaxis Regulation Of CGMP Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Projection Morphogenesis Endocytosis Nitric Oxide Metabolic Process Positive Regulation Of Cellular Metabolic Process CGMP Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Cellular Response To Heat Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Wounding Reactive Nitrogen Species Metabolic Process Regulation Of CGMP Metabolic Process Cell Morphogenesis Involved In Differentiation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus
Tagcloud ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Difference) ?			2j 6j buffer bxd coexpression congruent crosses dba distal extraordinary fluctuation gaba gabra1 gabra2 gabrb2 gabrb3 gabrg2 heritable massive naaa neurotransmission nos1 platforms remarkably subunits unlinked utrs zkscan1
Tagcloud (Intersection) ?