GSR and PJA1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GSR	PJA1
Gene Name		glutathione reductase	praja ring finger 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Cytosol External Side Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Glutathione-disulfide Reductase Activity Electron Carrier Activity Mercury (II) Reductase Activity Mercury Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Response To Reactive Oxygen Species Glutathione Metabolic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Cell Redox Homeostasis Detoxification Of Mercury Ion Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Protein Ubiquitination Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Glutathione NADH Carmustine 3,6-Dihydroxy-Xanthene-9-Propionic Acid Nicotinamide-Adenine-Dinucleotide 3-Sulfinoalanine Glutathionylspermidine Disulfide 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol Flavin-Adenine Dinucleotide Oxidized Glutathione Disulfide Meta-Nitro-Tyrosine 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID
Diseases
GWAS
Protein-Protein Interactions		3 interactors: C11orf49 OCM2 PJA1	36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440
Entrez ID		2936	64219
HPRD ID		00704	02335
Ensembl ID		ENSG00000104687	ENSG00000181191
Uniprot IDs		P00390	Q8NG27
PDB IDs		1ALG 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 3SQP 4GR1 4GRT 5GRT	2L0B
Enriched GO Terms of Interacting Partners?			Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		blister conductance contributed corneum dc displayed dominated ducts electrical frequencies galvanic hence hz means measurements nail pores pure situ skin sources stratum substantial sweat totally typically unrealiable warts waves
Tagcloud (Difference) ?		blister conductance contributed corneum dc displayed dominated ducts electrical frequencies galvanic hence hz means measurements nail pores pure situ skin sources stratum substantial sweat totally typically unrealiable warts waves
Tagcloud (Intersection) ?