GSR and PJA1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GSR	PJA1
Description		glutathione-disulfide reductase	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol External Side Of Plasma Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Glutathione-disulfide Reductase (NADPH) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glutathione Metabolic Process Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification	Protein Ubiquitination Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Glutathione NADH Carmustine 3,6-dihydroxy-xanthene-9-propionic acid 3-sulfino-L-alanine Glutathionylspermidine disulfide 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol Flavin adenine dinucleotide Glutathione disulfide 3-nitro-L-tyrosine 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID Cannabidiol Copper Medical Cannabis Nabiximols
Diseases
GWAS			Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		5 interacting genes: CDC42 CSTPP1 OCM2 PJA1 RNF26	63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		2936	64219
HPRD ID		00704	02335
Ensembl ID		ENSG00000104687	ENSG00000181191
Uniprot IDs		P00390 V9HW90	Q8NG27
PDB IDs		1ALG 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 3SQP 4GR1 4GRT 5GRT	2L0B
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity	Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator
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