GRM8 and PIAS2

Number of citations of the paper that reports this interaction (PMID 16144832)
18

Data Source:
HPRD (two hybrid)

		GRM8	PIAS2
Gene Name		glutamate receptor, metabotropic 8	protein inhibitor of activated STAT, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Presynaptic Membrane	Nucleus PML Body Nuclear Speck
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Glutamate Receptor Activity	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Visual Perception Sensory Perception Of Smell Negative Regulation Of CAMP Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		4 interactors: FLNA GPRASP1 PIAS1 PIAS2	68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451
Entrez ID		2918	9063
HPRD ID		03071	06944
Ensembl ID		ENSG00000179603	ENSG00000078043
Uniprot IDs		O00222	O75928
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling G-protein Coupled Receptor Catabolic Process Intracellular Receptor Signaling Pathway Endosomal Transport Peptidyl-lysine Modification Positive Regulation Of Smooth Muscle Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Catabolic Process MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription Regulation Of Smooth Muscle Cell Differentiation Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Regulation Of Protein Sumoylation Receptor Catabolic Process Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Actin Crosslink Formation Cytoplasmic Sequestering Of Protein Cytoplasmic Transport Endosome To Lysosome Transport Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Lysosomal Transport Receptor Clustering RNA Metabolic Process JAK-STAT Cascade Peptidyl-amino Acid Modification Epithelial To Mesenchymal Transition Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling
Tagcloud ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?