GRM8 and GPRASP1

Number of citations of the paper that reports this interaction (PMID 15452121)
38

Data Source:
HPRD (in vitro)

		GRM8	GPRASP1
Gene Name		glutamate receptor, metabotropic 8	G protein-coupled receptor associated sorting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Presynaptic Membrane	Cytoplasm
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Glutamate Receptor Activity	Protein Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Visual Perception Sensory Perception Of Smell Negative Regulation Of CAMP Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic	Endosome To Lysosome Transport G-protein Coupled Receptor Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		4 interactors: FLNA GPRASP1 PIAS1 PIAS2	47 interactors: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1
Entrez ID		2918	9737
HPRD ID		03071	02333
Ensembl ID		ENSG00000179603	ENSG00000198932
Uniprot IDs		O00222	Q5JY77
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling G-protein Coupled Receptor Catabolic Process Intracellular Receptor Signaling Pathway Endosomal Transport Peptidyl-lysine Modification Positive Regulation Of Smooth Muscle Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Catabolic Process MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription Regulation Of Smooth Muscle Cell Differentiation Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Regulation Of Protein Sumoylation Receptor Catabolic Process Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Actin Crosslink Formation Cytoplasmic Sequestering Of Protein Cytoplasmic Transport Endosome To Lysosome Transport Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Lysosomal Transport Receptor Clustering RNA Metabolic Process JAK-STAT Cascade Peptidyl-amino Acid Modification Epithelial To Mesenchymal Transition Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Cytosolic Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Response To Stimulus Cellular Metal Ion Homeostasis Cell-cell Signaling Positive Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Signaling Signal Transduction Metal Ion Homeostasis Cell Communication Blood Circulation Cellular Chemical Homeostasis Ion Homeostasis Response To Stimulus Neuropeptide Signaling Pathway Regulation Of Muscle Contraction G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Homeostasis Chemical Homeostasis Regulation Of Blood Pressure Tachykinin Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Opioid Receptor Signaling Pathway Regulation Of Vasoconstriction Positive Regulation Of Uterine Smooth Muscle Contraction Neurological System Process Homeostatic Process Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Blood Pressure Behavior Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of CAMP Metabolic Process Response To Abiotic Stimulus Regulation Of Adenylate Cyclase Activity
Tagcloud ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed
Tagcloud (Difference) ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed
Tagcloud (Intersection) ?