GRM8 and GPRASP1

Number of citations: 0 (PubMedID 15452121)
Data Source: HPRD (in vitro)

		GRM8	GPRASP1
Name		glutamate metabotropic receptor 8	G protein-coupled receptor associated sorting protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	None
Drugs		Glutamic acid	None
GWAS		Anti-saccade response ( 25387707 29064472 ) Anxiety ( 33859377 ) Carotid atherosclerosis in HIV infection ( 20009918 ) Chemerin levels ( 20237162 ) Creutzfeldt-Jakob disease (sporadic) ( 25918841 ) Depression (quantitative trait) ( 20800221 ) Experiencing mood swings ( 29500382 ) Fasting glucose change (long-term) ( 31263163 ) Feeling hurt ( 29500382 ) Feeling worry ( 29500382 ) Gastroesophageal reflux disease ( 31527586 34187846 ) General factor of neuroticism ( 30867560 ) Hearing function ( 25060954 ) Hip circumference adjusted for BMI ( 28552196 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Neurociticism ( 29500382 ) Response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Smoking initiation ( 30617275 ) Type 2 diabetes ( 32499647 ) Worry too long after an embarrassing experience ( 29500382 ) Worry/vulnerability (special factor of neuroticism) ( 30867560 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2	48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1
Entrez ID		2918	9737
HPRD ID		03071	02333
Ensembl ID		ENSG00000179603	ENSG00000198932
Uniprot IDs		A0A9L9PYG5 O00222	Q5JY77
PDB IDs		6BSZ 6BT5 6E5V	Not available
GO Terms Enriched among Interactors		SUMO Ligase Activity SUMO Transferase Activity Protein Sumoylation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential PML Body Transcription Coregulator Activity G Protein-coupled Receptor Catabolic Process Glycoprotein Ib-IX-V Complex Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Formation Of Radial Glial Scaffolds DNA-binding Transcription Factor Binding Tubulin Deacetylation Negative Regulation Of Apoptotic Process Myb Complex Establishment Of Sertoli Cell Barrier Transcription Corepressor Activity Protein Localization To Bicellular Tight Junction Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential ATP-dependent Protein Binding Blood Coagulation, Intrinsic Pathway Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Transcription By RNA Polymerase I Ubiquitin Protein Ligase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Platelet Activation Protein Deacetylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Sumoylation	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade