GRM8 and PIAS1

Number of citations of the paper that reports this interaction (PMID 16144832)
18

Data Source:
HPRD (in vitro, two hybrid)

		GRM8	PIAS1
Gene Name		glutamate receptor, metabotropic 8	protein inhibitor of activated STAT, 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Presynaptic Membrane	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Glutamate Receptor Activity	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Visual Perception Sensory Perception Of Smell Negative Regulation Of CAMP Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated JAK-STAT Cascade Spermatogenesis Protein Sumoylation Cytokine-mediated Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		L-Glutamic Acid
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Depression (quantitative trait) ( 20800221)	Major depressive disorder ( 23377640)
Protein-Protein Interactions		4 interactors: FLNA GPRASP1 PIAS1 PIAS2	92 interactors: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CARM1 CASP8 CBS CEBPA CEBPE CHUK CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 ESR1 ESR2 FLI1 GATA4 GLUL GRM8 HIC1 HTT JUN L3MBTL2 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRMT1 PRMT6 PRPF40A PTK2 PTPN1 RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SIAH1 SIAH2 SKIL SMAD1 SMAD4 SMAD7 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO2 SUMO3 TBP TP53 TP73 TRIM27 TRIM55 TRIM63 UBE2I YWHAZ ZNF451 ZNF76
Entrez ID		2918	8554
HPRD ID		03071	16029
Ensembl ID		ENSG00000179603	ENSG00000033800
Uniprot IDs		O00222	O75925 Q1XBU8
PDB IDs			1V66
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling G-protein Coupled Receptor Catabolic Process Intracellular Receptor Signaling Pathway Endosomal Transport Peptidyl-lysine Modification Positive Regulation Of Smooth Muscle Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Catabolic Process MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription Regulation Of Smooth Muscle Cell Differentiation Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Regulation Of Protein Sumoylation Receptor Catabolic Process Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Actin Crosslink Formation Cytoplasmic Sequestering Of Protein Cytoplasmic Transport Endosome To Lysosome Transport Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Lysosomal Transport Receptor Clustering RNA Metabolic Process JAK-STAT Cascade Peptidyl-amino Acid Modification Epithelial To Mesenchymal Transition Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Substance Macromolecule Biosynthetic Process Response To Organic Substance Cellular Response To Stimulus Regulation Of Cellular Process Multicellular Organismal Development Biosynthetic Process Response To Stimulus Regulation Of Signaling Cell Differentiation Organ Development Signaling Signal Transduction Anatomical Structure Development Developmental Process Regulation Of Signal Transduction
Tagcloud ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?