GRM8

Gene Name		glutamate receptor, metabotropic 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Presynaptic Membrane
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Visual Perception Sensory Perception Of Smell Negative Regulation Of CAMP Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		L-Glutamic Acid
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Depression (quantitative trait) ( 20800221)
Protein-protein Interactions		4 interactors: FLNA GPRASP1 PIAS1 PIAS2
Entrez ID		2918
HPRD ID		03071
Ensembl ID		ENSG00000179603
Uniprot IDs		O00222
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling G-protein Coupled Receptor Catabolic Process Intracellular Receptor Signaling Pathway Endosomal Transport Peptidyl-lysine Modification Positive Regulation Of Smooth Muscle Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Catabolic Process MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription Regulation Of Smooth Muscle Cell Differentiation Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Regulation Of Protein Sumoylation Receptor Catabolic Process Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Actin Crosslink Formation Cytoplasmic Sequestering Of Protein Cytoplasmic Transport Endosome To Lysosome Transport Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Lysosomal Transport Receptor Clustering RNA Metabolic Process JAK-STAT Cascade Peptidyl-amino Acid Modification Epithelial To Mesenchymal Transition Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		16p11 17q21 2p21 acot7 autism auts2 cask categorised cnvs crebbp ctnnd2 delineating exonic homozygous incidental instrumental iq kb med13l microdeletion morbid ndds neurodevelopmental nrxn3 omim pafah1b1 satb2 sizing undiagnosed