GRM8 and DNAJC5

Number of citations: 64 (PubMedID 29997244)
Data Source: BioGRID (fluorescent resonance energy transfer)

		GRM8	DNAJC5
Name		glutamate metabotropic receptor 8	DnaJ heat shock protein family (Hsp40) member C5
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs		Glutamic acid	None
GWAS		Anti-saccade response ( 25387707 29064472 ) Anxiety ( 33859377 ) Carotid atherosclerosis in HIV infection ( 20009918 ) Chemerin levels ( 20237162 ) Creutzfeldt-Jakob disease (sporadic) ( 25918841 ) Depression (quantitative trait) ( 20800221 ) Experiencing mood swings ( 29500382 ) Fasting glucose change (long-term) ( 31263163 ) Feeling hurt ( 29500382 ) Feeling worry ( 29500382 ) Gastroesophageal reflux disease ( 31527586 34187846 ) General factor of neuroticism ( 30867560 ) Hearing function ( 25060954 ) Hip circumference adjusted for BMI ( 28552196 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Neurociticism ( 29500382 ) Response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Smoking initiation ( 30617275 ) Type 2 diabetes ( 32499647 ) Worry too long after an embarrassing experience ( 29500382 ) Worry/vulnerability (special factor of neuroticism) ( 30867560 )	Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 )
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		2918	80331
HPRD ID		03071	08539
Ensembl ID		ENSG00000179603	ENSG00000101152
Uniprot IDs		A0A9L9PYG5 O00222	Q9H3Z4
PDB IDs		6BSZ 6BT5 6E5V	2N04 2N05
GO Terms Enriched among Interactors		SUMO Ligase Activity SUMO Transferase Activity Protein Sumoylation Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential PML Body Transcription Coregulator Activity G Protein-coupled Receptor Catabolic Process Glycoprotein Ib-IX-V Complex Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Formation Of Radial Glial Scaffolds DNA-binding Transcription Factor Binding Tubulin Deacetylation Negative Regulation Of Apoptotic Process Myb Complex Establishment Of Sertoli Cell Barrier Transcription Corepressor Activity Protein Localization To Bicellular Tight Junction Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential ATP-dependent Protein Binding Blood Coagulation, Intrinsic Pathway Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Transcription By RNA Polymerase I Ubiquitin Protein Ligase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Platelet Activation Protein Deacetylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Sumoylation	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation