PPP2CA and GABRB3

Number of citations of the paper that reports this interaction (PMID 14724252)
58

Data Source:
HPRD (in vitro)

		PPP2CA	GABRB3
Gene Name		protein phosphatase 2, catalytic subunit, alpha isozyme	gamma-aminobutyric acid (GABA) A receptor, beta 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Dimerization Activity GABA Receptor Binding	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Gene Expression Regulation Of Receptor Activity Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Protein Autophosphorylation Regulation Of Growth Regulation Of Protein Catabolic Process Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Protein Heterotrimerization Positive Regulation Of Protein Serine/threonine Kinase Activity	Transport Signal Transduction Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Negative Regulation Of Neuron Apoptotic Process Transmembrane Transport Palate Development Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport
Pathways		Signaling by GPCR Integration of energy metabolism Signaling by FGFR in disease Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Initiation of Nuclear Envelope Reformation Mitotic G1-G1/S phases ERK/MAPK targets Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase M Phase Toll Like Receptor TLR6:TLR2 Cascade APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Nuclear Envelope Reassembly Innate Immune System Nonsense-Mediated Decay (NMD) E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Signaling by FGFR Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Longevity ( 20834067)
Protein-Protein Interactions		71 interactors: ADCY8 AKT1 APC AXIN1 BCL2 BEST1 BMPR1B CAD CAV1 CCNG1 CCNG2 CDK2 CDK6 CDKN2C CHEK2 CXCR2 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 MAPK1 MAPK3 MAPT MID1 MRPS26 MYH9 NME2 NXN PACS1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTN PXN RACGAP1 RBL2 RELA RHO RHOB RPS6KB1 RRAS SET SGK1 SGOL1 SGOL2 STAT5A STAT5B STRN TLX1 TP53 TRIP13 TSC2 VAC14 VDR XRN1	8 interactors: AKAP5 ARFGEF2 GNB2L1 MEOX2 PPP2CA PRKACA PRKCA UBQLN1
Entrez ID		5515	2562
HPRD ID		08912	08844
Ensembl ID			ENSG00000166206
Uniprot IDs		B3KUN1 P67775	B2RCW8 P28472
PDB IDs		2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Process Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Signaling Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Regulation Of Phosphorylation Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Apoptotic Process Developmental Process Regulation Of Metabolic Process Response To Organic Substance Programmed Cell Death Mitotic Cell Cycle Process Regulation Of Kinase Activity Cellular Response To Organic Substance Anatomical Structure Development Cell Surface Receptor Signaling Pathway Cell Death Death Regulation Of Cellular Protein Metabolic Process System Development Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Organ Development Multicellular Organismal Development Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Response To Hormone Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Death Regulation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction	Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Intracellular Signal Transduction Inactivation Of MAPK Activity Histone H3-T6 Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Positive Regulation Of CAMP Biosynthetic Process Nuclear Envelope Organization Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of CAMP Biosynthetic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Nucleus Organization Endomembrane System Organization Desmosome Organization Cell Death Death Positive Regulation Of Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Lyase Activity Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Rhodopsin Mediated Signaling Pathway
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Intersection) ?