PPP2CA and GABRB3

Number of citations of the paper that reports this interaction (PubMedID 14724252)
49

Data Source:
HPRD (in vitro)

		PPP2CA	GABRB3
Description		protein phosphatase 2 catalytic subunit alpha	gamma-aminobutyric acid type A receptor subunit beta3
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Spindle Pole Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex INTAC Complex	Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity Identical Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Mesoderm Development Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Polymerization Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Meiotic Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of G1/S Transition Of Mitotic Cell Cycle	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Nervous System Development Brain Development Learning Memory Response To Xenobiotic Stimulus Reproductive Behavior Cerebellum Development Monoatomic Ion Transmembrane Transport Social Behavior Exploration Behavior Circadian Sleep/wake Cycle, REM Sleep Neuron Development Synaptic Transmission, GABAergic Roof Of Mouth Development Hard Palate Development Inhibitory Postsynaptic Potential Inner Ear Receptor Cell Development Innervation Motor Behavior Cellular Response To Zinc Ion Cellular Response To Histamine Response To Anesthetic Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Piperazine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Muscimol 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS			Body mass index ( 28892062) Cognitive performance ( 19734545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 20834067) Pericalcarine cortex volume ( 31530798) Postprandial triglyceride response ( 32603185) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		101 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAP4K1 MAP4K3 MAP4K4 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 POLR2A PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 UBC VAC14 VDR XRN1 YPEL3	8 interacting genes: AKAP5 ARFGEF2 MEOX2 PPP2CA PRKACA PRKCA RACK1 UBQLN1
Entrez ID		5515	2562
HPRD ID		08912	08844
Ensembl ID		ENSG00000113575	ENSG00000166206
Uniprot IDs		B3KQ51 B3KUN1 P67775	B2RCW8 P28472 X5DQY4
PDB IDs		2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 4NY3 5W0W 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	4COF 5O8F 5OJM 6A96 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6QFA 7PBD 7PBZ 7PC0 7QN5 7QN6 7QN7 7QN8 7QN9 7QNA 7QNB 7QNC 7QND 7QNE 8PVB 9CSB 9CTJ 9CX7 9CXA 9CXC 9EQG
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Cytosol Regulation Of Cell Population Proliferation Protein Phosphatase Regulator Activity Protein Phosphorylation Protein Phosphatase Type 2A Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Apoptotic Process Regulation Of Cell Cycle Programmed Cell Death Cell Death Protein Phosphatase 2A Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cytoplasm Nucleus Response To Ketone Response To Lipid Regulation Of Mitotic Cell Cycle Response To Starvation Positive Regulation Of Intracellular Signal Transduction Protein Modification Process Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Identical Protein Binding Positive Regulation Of Apoptotic Process Cellular Response To Stress Protein Metabolic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound	GABA Receptor Binding Protein Kinase A Regulatory Subunit Binding Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Perinuclear Region Of Cytoplasm Protein Serine/threonine Phosphatase Complex Positive Regulation Of Establishment Of Protein Localization Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Signal Transduction Negative Regulation Of Glycolytic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of ATP Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Fluid Shear Stress Regulation Of Calcium Ion Transport Negative Regulation Of Smoothened Signaling Pathway Response To Fluid Shear Stress Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium-mediated Signaling Regulation Of Transport Positive Regulation Of Transport Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Protein Localization Regulation Of Metal Ion Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of ATP Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Cellular Response To Carbohydrate Stimulus Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Purine Nucleotide Metabolic Process
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