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PPP2CA and TRIM35
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PPP2CA
TRIM35
Description
protein phosphatase 2 catalytic subunit alpha
tripartite motif containing 35
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Spindle Pole
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
INTAC Complex
Nucleus
Cytoplasm
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Mesoderm Development
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Polymerization
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
RNA Polymerase II Transcription Initiation Surveillance
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Apoptotic Process
Protein Ubiquitination
Positive Regulation Of Apoptotic Process
Suppression Of Viral Release By Host
Innate Immune Response
Negative Regulation Of Mitotic Cell Cycle
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Interferon gamma signaling
Drugs
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Chronotype (
30696823
)
Crohn's disease (
26192919
)
Inflammatory bowel disease (
26192919
)
Lung cancer (
28604730
)
Interacting Genes
101 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAP4K1
MAP4K3
MAP4K4
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
POLR2A
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
UBC
VAC14
VDR
XRN1
YPEL3
50 interacting genes:
ADIPOQ
ANTXR1
BANP
CABP2
COL8A1
DTX2
ENKD1
FNDC3B
GNMT
HNRNPA2B1
IGFN1
KANK2
LCK
LMO1
MGAT5B
NRF1
PAN2
PARD6B
PDCD5
PHF24
PKM
PPP2CA
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QARS1
SHC3
SMARCB1
TCEANC
TRAPPC6A
TRIM10
TRIM11
TRIM5
TRIM55
TRIM63
TSG101
TSSK3
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2K
UBE2U
UBE2W
USP2
USP49
ZNF410
Entrez ID
5515
23087
HPRD ID
08912
15553
Ensembl ID
ENSG00000113575
ENSG00000104228
Uniprot IDs
B3KQ51
B3KUN1
P67775
E5RGB3
Q9UPQ4
PDB IDs
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
4NY3
5W0W
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Cytosol
Regulation Of Cell Population Proliferation
Protein Phosphatase Regulator Activity
Protein Phosphorylation
Protein Phosphatase Type 2A Complex
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Apoptotic Process
Regulation Of Cell Cycle
Programmed Cell Death
Cell Death
Protein Phosphatase 2A Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Nucleus
Response To Ketone
Response To Lipid
Regulation Of Mitotic Cell Cycle
Response To Starvation
Positive Regulation Of Intracellular Signal Transduction
Protein Modification Process
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Identical Protein Binding
Positive Regulation Of Apoptotic Process
Cellular Response To Stress
Protein Metabolic Process
Response To Nutrient Levels
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Post-translational Protein Modification
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification Process
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Activity
Transferase Activity
Host-mediated Suppression Of Symbiont Invasion
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Host-mediated Perturbation Of Symbiont Process
Macromolecule Metabolic Process
Modulation Of Process Of Another Organism
Protein Binding
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
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Tagcloud (Intersection)
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