PPP2CA and STRN

Number of citations of the paper that reports this interaction (PubMedID 10681496)
29

Data Source:
HPRD (in vivo)

		PPP2CA	STRN
Description		protein phosphatase 2 catalytic subunit alpha	striatin
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Spindle Pole Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex INTAC Complex	Cytoplasm Cytosol Bicellular Tight Junction Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane FAR/SIN/STRIPAK Complex Postsynapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity	Protein Binding Calmodulin Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Mesoderm Development Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Polymerization Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Meiotic Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of G1/S Transition Of Mitotic Cell Cycle	Locomotory Behavior Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Dendrite Development Bicellular Tight Junction Assembly
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Extra-nuclear estrogen signaling Signaling by cytosolic PDGFRA and PDGFRB fusion proteins ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs		Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 27863252) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) PR interval ( 32439900) QRS duration ( 27659466 27577874) Red cell distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549 32154731)
Interacting Genes		101 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAP4K1 MAP4K3 MAP4K4 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 POLR2A PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 UBC VAC14 VDR XRN1 YPEL3	12 interacting genes: ATF7IP CALM1 CAV1 ESR1 GNAI1 LNX1 PDCD10 PPP2CA PPP2R1A PPP2R1B RINT1 TFIP11
Entrez ID		5515	6801
HPRD ID		08912	18124
Ensembl ID		ENSG00000113575	ENSG00000115808
Uniprot IDs		B3KQ51 B3KUN1 P67775	O43815
PDB IDs		2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 4NY3 5W0W 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Cytosol Regulation Of Cell Population Proliferation Protein Phosphatase Regulator Activity Protein Phosphorylation Protein Phosphatase Type 2A Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Apoptotic Process Regulation Of Cell Cycle Programmed Cell Death Cell Death Protein Phosphatase 2A Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cytoplasm Nucleus Response To Ketone Response To Lipid Regulation Of Mitotic Cell Cycle Response To Starvation Positive Regulation Of Intracellular Signal Transduction Protein Modification Process Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Identical Protein Binding Positive Regulation Of Apoptotic Process Cellular Response To Stress Protein Metabolic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound	FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Communication By Electrical Coupling Intracellular Signal Transduction INTAC Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Hippo Signaling Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Kinase Binding T Cell Homeostasis Nuclear RNA Surveillance Membrane Raft Fibroblast Proliferation RNA Surveillance Sister Chromatid Cohesion Protein Phosphatase Regulator Activity Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Muscle System Process Regulation Of Signaling Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Endothelial Cell Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Regulation Of Action Potential Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Lymphocyte Homeostasis Regulation Of Nitric Oxide Metabolic Process Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Response To Metal Ion
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