PPP2CA and MAPT

Number of citations of the paper that reports this interaction (PubMedID 1330687)
0

Data Source:
HPRD (in vivo, in vitro)

		PPP2CA	MAPT
Description		protein phosphatase 2 catalytic subunit alpha	microtubule associated protein tau
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Spindle Pole Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex INTAC Complex	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Protein-folding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Mesoderm Development Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Polymerization Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Meiotic Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of G1/S Transition Of Mitotic Cell Cycle	Microtubule Cytoskeleton Organization Microglial Cell Activation DNA Damage Response Cell-cell Signaling Synapse Assembly Learning Or Memory Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Protein Homooligomerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Localization Negative Regulation Of Tubulin Deacetylation Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18
Diseases			Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			A body shape index ( 34021172) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701 33861876) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156 31710517) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Left–right brain asymmetry ( 33723403) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 31660654 20070850 20711177 21044948 21292315 34064523 21738487 22438815 24511991 24842889 25064009 28892059 19915575) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 31059154 30089514 21685912) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Subcortical brain region volumes ( 25607358) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		101 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAP4K1 MAP4K3 MAP4K4 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 POLR2A PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 UBC VAC14 VDR XRN1 YPEL3	127 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CREBBP CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FYN GSK3A GSK3B HDAC6 HNRNPC HOOK3 HSPA8 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK3 MARK4 MASP1 MDM2 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTGES3 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TRIM11 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ
Entrez ID		5515	4137
HPRD ID		08912	01142
Ensembl ID		ENSG00000113575	ENSG00000186868
Uniprot IDs		B3KQ51 B3KUN1 P67775	A0A7I2PJZ2 A0A7I2PLE3 B3KTM0 P10636
PDB IDs		2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 4NY3 5W0W 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI 7EYC 7KQK 7MKF 7MKG 7MKH 7NRQ 7NRS 7NRT 7NRV 7NRX 7P65 7P66 7P67 7P68 7P6A 7P6B 7P6C 7P6D 7P6E 7PQC 7PQP 7QJV 7QJW 7QJX 7QJY 7QJZ 7QK1 7QK2 7QK3 7QK5 7QK6 7QKF 7QKG 7QKH 7QKI 7QKJ 7QKK 7QKL 7QKM 7QKU 7QKV 7QKW 7QKX 7QKY 7QKZ 7QL0 7QL1 7QL2 7QL3 7QL4 7R4T 7R5H 7SP1 7U0Z 7UPE 7UPF 7UPG 7YMN 7YPG 8AZU 8BGS 8BGV 8BYN 8CAQ 8CAX 8FNZ 8FUG 8FYU 8G54 8G55 8G58 8GCK 8KDX 8OH2 8OHI 8OHP 8OI0 8OP0 8OPI 8ORE 8ORF 8ORG 8OT6 8OT9 8OTC 8OTG 8OTH 8OTI 8OTJ 8P34 8PII 8PPO 8Q27 8Q2J 8Q2K 8Q2L 8Q7F 8Q7L 8Q7M 8Q7P 8Q7T 8Q88 8Q8C 8Q8D 8Q8E 8Q8F 8Q8L 8Q8M 8Q8R 8Q8S 8Q8U 8Q8V 8Q8W 8Q8X 8Q8Y 8Q8Z 8Q92 8Q97 8Q98 8Q99 8Q9A 8Q9B 8Q9C 8Q9D 8Q9E 8Q9F 8Q9G 8Q9H 8Q9I 8Q9J 8Q9K 8Q9L 8Q9M 8Q9O 8QCP 8QCR 8QDV 8QJJ 8R3T 8SEH 8SEI 8TTL 8TTN 8UQ7 8V1N 8WCP 8ZWL 8ZWM 8ZX6 9B4L 9B4M 9B4N 9B4O 9BBL 9BBM 9BXI 9BXO 9BXQ 9BXR 9CGX 9CGZ 9CZI 9CZL 9EO7 9EO9 9EOE 9EOG 9EOH 9ERM 9ERN 9ERO 9G13 9GG0 9GG1 9GG6 9H5G 9H5J 9HBB 9MR8
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Cytosol Regulation Of Cell Population Proliferation Protein Phosphatase Regulator Activity Protein Phosphorylation Protein Phosphatase Type 2A Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Apoptotic Process Regulation Of Cell Cycle Programmed Cell Death Cell Death Protein Phosphatase 2A Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cytoplasm Nucleus Response To Ketone Response To Lipid Regulation Of Mitotic Cell Cycle Response To Starvation Positive Regulation Of Intracellular Signal Transduction Protein Modification Process Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Identical Protein Binding Positive Regulation Of Apoptotic Process Cellular Response To Stress Protein Metabolic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Kinase Activity Protein Modification Process Protein Metabolic Process Tau Protein Binding Intracellular Signal Transduction Protein Phosphorylation Phosphorylation Cytoplasm ATP Binding Cytosol Transferase Activity Nucleotide Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Macromolecule Metabolic Process Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Stress Response To Stress Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Nucleus Positive Regulation Of Cell Communication Regulation Of Protein-containing Complex Assembly Programmed Cell Death Cell Death Apoptotic Process Tau-protein Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Metabolic Process MAP Kinase Activity Regulation Of Immune System Process Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?