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GRIN2D and GRIN1
Number of citations of the paper that reports this interaction (PMID
12191494
)
19
Data Source:
HPRD
(in vivo, in vitro)
GRIN2D
GRIN1
Gene Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Postsynaptic Membrane
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Molecular Function
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Protein Binding
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Biological Process
Startle Response
Signal Transduction
Synaptic Transmission
Adult Locomotory Behavior
Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Sensory Perception Of Pain
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Tenocyclidine
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Protein-Protein Interactions
33 interactors:
ABL1
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG4
DLGAP4
DNM1
DUSP4
FUS
GRIN1
HNRNPU
HRAS
HSPA1A
IL16
INA
INADL
MAP2
MAP2K2
NANOS1
NF1
PPP2R1A
PPP2R2A
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SPTAN1
SYNGAP1
TJP1
TRAF3
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
Entrez ID
2906
2902
HPRD ID
04095
15926
Ensembl ID
ENSG00000105464
ENSG00000176884
Uniprot IDs
O15399
Q59G17
Q05586
Q59GW0
Q5VSF9
PDB IDs
2HQW
2NR1
3BYA
Enriched GO Terms of Interacting Partners
?
Nervous System Development
Regulation Of MAPK Cascade
Regulation Of Long-term Neuronal Synaptic Plasticity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Neurogenesis
Cell Development
Locomotion
Generation Of Neurons
Intracellular Signal Transduction
Neuron Projection Development
Cell Differentiation
Regulation Of Cellular Component Organization
Regulation Of Neuronal Synaptic Plasticity
Cellular Response To Stimulus
Neuron Differentiation
Enzyme Linked Receptor Protein Signaling Pathway
Cell Projection Organization
Signaling
Cell Morphogenesis Involved In Differentiation
Axonogenesis
MyD88-independent Toll-like Receptor Signaling Pathway
Neuron Development
Cell Communication
Apoptotic Process
Response To Organic Substance
Signal Transduction
Axon Guidance
Axon Development
Programmed Cell Death
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Cell Death
Toll-like Receptor 4 Signaling Pathway
Death
Regulation Of Neuron Death
Developmental Process
Neuron Projection Morphogenesis
Response To Ammonium Ion
Immune Response-regulating Signaling Pathway
Regulation Of Metabolic Process
Response To Stimulus
Response To Morphine
Regulation Of Intracellular Signal Transduction
Cell-cell Signaling
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Multicellular Organismal Development
Response To External Stimulus
Toll-like Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Tagcloud
?
6j
6jxm
atg
autosomes
backcross
codon
crosses
dispersed
egr
epsilon
espilon
exons
f1xc57bl
flanking
grinl
interspecific
mapping
nucleas
polyadenylation
primer
s1
spans
spl
spretus
termination
zeta
Tagcloud (Difference)
?
6j
6jxm
atg
autosomes
backcross
codon
crosses
dispersed
egr
epsilon
espilon
exons
f1xc57bl
flanking
grinl
interspecific
mapping
nucleas
polyadenylation
primer
s1
spans
spl
spretus
termination
zeta
Tagcloud (Intersection)
?