GRIN2D and CDH2

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		GRIN2D	CDH2
Description		glutamate ionotropic receptor NMDA type subunit 2D	cadherin 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Extracellular Matrix Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Anchoring Junction Presynapse
	Molecular Function	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate Binding Voltage-gated Monoatomic Cation Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	RNA Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Startle Response Monoatomic Ion Transport Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To L-glutamate Positive Regulation Of Excitatory Postsynaptic Potential	Cell Morphogenesis Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Telencephalon Development Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Striated Muscle Cell Differentiation Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Synaptic Vesicle Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS			Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Systemic lupus erythematosus ( 32771030) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC
Entrez ID		2906	1000
HPRD ID		04095	00226
Ensembl ID		ENSG00000105464	ENSG00000170558
Uniprot IDs		O15399 Q59G17	C9J126 P19022
PDB IDs		7YFF 7YFL 7YFM 7YFO 7YFR 8E96 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Synapse Protein Kinase Binding Regulation Of Cytoskeleton Organization Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Organelle Organization Regulation Of Biological Quality Regulation Of Long-term Neuronal Synaptic Plasticity Cytosol Plasma Membrane Cytoplasm Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Neuron Apoptotic Process Dendrite Cell Junction Receptor Clustering Trans-synaptic Signaling Neuron Projection Regulation Of Anatomical Structure Morphogenesis Regulation Of Transport Synaptic Signaling Response To Morphine Diacylglycerol-dependent Serine/threonine Kinase Activity Perinuclear Region Of Cytoplasm MAPK Cascade Regulation Of Cellular Localization Schwann Cell Development Synaptic Membrane Regulation Of Neuron Apoptotic Process Positive Regulation Of Synaptic Transmission Postsynaptic Density Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Protein Localization Learning Or Memory Learning Negative Regulation Of Protein Ubiquitination Regulation Of Developmental Process Regulation Of Microtubule Cytoskeleton Organization Disordered Domain Specific Binding	Adherens Junction Cell-cell Adhesion Cadherin Binding Cell Adhesion Catenin Complex Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Signal Transduction Cell-cell Junction Assembly Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Organization Glutamate-gated Calcium Ion Channel Activity Cell-cell Junction Cell Surface Receptor Signaling Pathway Postsynaptic Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Postsynaptic Density Anatomical Structure Morphogenesis Cell Junction Assembly Excitatory Postsynaptic Potential D5 Dopamine Receptor Binding Cell Junction Organization Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Signal Transduction Catenin-TCF7L2 Complex Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Beta-catenin Binding Ligand-gated Monoatomic Ion Channel Activity Anchoring Junction Cellular Response To Oxygen-containing Compound Signal Transduction Cell-cell Adhesion Mediated By Cadherin Ligand-gated Ion Channel Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Synaptic Transmission, Glutamatergic Regulation Of Neuroblast Proliferation Presynaptic Membrane Neuroblast Proliferation Intercalated Disc NMDA Glutamate Receptor Activity Glutamate Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission
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