GRIN2D and INA

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		GRIN2D	INA
Description		glutamate ionotropic receptor NMDA type subunit 2D	internexin neuronal intermediate filament protein alpha
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Space Cytoplasm Intermediate Filament Neurofilament Cytoplasmic Ribonucleoprotein Granule Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate Binding Voltage-gated Monoatomic Cation Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Startle Response Monoatomic Ion Transport Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To L-glutamate Positive Regulation Of Excitatory Postsynaptic Potential	Nervous System Development Substantia Nigra Development Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Neurofilament Cytoskeleton Organization Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Migraine ( 22683712) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 23974872 25056061 28991256 29483656)
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	5 interacting genes: FXR1 GRIN1 GRIN2D STAU1 TANC1
Entrez ID		2906	9118
HPRD ID		04095	05628
Ensembl ID		ENSG00000105464	ENSG00000148798
Uniprot IDs		O15399 Q59G17	Q16352
PDB IDs		7YFF 7YFL 7YFM 7YFO 7YFR 8E96 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Synapse Protein Kinase Binding Regulation Of Cytoskeleton Organization Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Organelle Organization Regulation Of Biological Quality Regulation Of Long-term Neuronal Synaptic Plasticity Cytosol Plasma Membrane Cytoplasm Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Neuron Apoptotic Process Dendrite Cell Junction Receptor Clustering Trans-synaptic Signaling Neuron Projection Regulation Of Anatomical Structure Morphogenesis Regulation Of Transport Synaptic Signaling Response To Morphine Diacylglycerol-dependent Serine/threonine Kinase Activity Perinuclear Region Of Cytoplasm MAPK Cascade Regulation Of Cellular Localization Schwann Cell Development Synaptic Membrane Regulation Of Neuron Apoptotic Process Positive Regulation Of Synaptic Transmission Postsynaptic Density Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Protein Localization Learning Or Memory Learning Negative Regulation Of Protein Ubiquitination Regulation Of Developmental Process Regulation Of Microtubule Cytoskeleton Organization Disordered Domain Specific Binding	Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Glutamate Binding NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Dendrite Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Synapse Ligand-gated Ion Channel Signaling Pathway Regulation Of Long-term Synaptic Potentiation Neuron Projection Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Visual Learning Visual Behavior Excitatory Postsynaptic Potential Cytoplasmic Ribonucleoprotein Granule Calcium Ion Transmembrane Import Into Cytosol Propylene Metabolic Process Cytoplasmic Stress Granule Associative Learning Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Response To Amino Acid Regulation Of Nervous System Process Response To Glycine Positive Regulation Of Cell Communication Positive Regulation Of Signaling Dendritic Spine Glycine-gated Cation Channel Activity Learning Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Monoatomic Ion Channel Activity Calcium-mediated Signaling Positive Regulation By Virus Of Viral Protein Levels In Host Cell Nervous System Process Calcium Ion Transmembrane Transport Germ Cell Development LncRNA-mediated Post-transcriptional Gene Silencing RNA Strand Annealing Activity
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